SMAD6

Entrez Summary: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014].
UniProt Summary: Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:9436979}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LJH685 5μM R02 exp73	1.99
TRAIL 50ng/ml R00 exp36	2.17

MH1
MH2

transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
type I activin receptor binding
zygotic specification of dorsal/ventral axis
negative regulation of SMAD protein complex assembly
regulation of SMAD protein complex assembly
mitral valve morphogenesis
dorsal/ventral axis specification
type I transforming growth factor beta receptor binding
mitral valve development
negative regulation of pathway-restricted SMAD protein phosphorylation
I-SMAD binding
co-SMAD binding
response to laminar fluid shear stress
pulmonary valve morphogenesis
pulmonary valve development
R-SMAD binding
atrioventricular valve morphogenesis
atrioventricular valve development
aortic valve morphogenesis
outflow tract septum morphogenesis
positive regulation of pri-miRNA transcription by RNA polymerase II
aortic valve development
response to fluid shear stress
embryonic axis specification
semi-lunar valve development
regulation of pri-miRNA transcription by RNA polymerase II
negative regulation of osteoblast differentiation
coronary vasculature development
negative regulation of BMP signaling pathway
aorta development
heart valve morphogenesis
regulation of pathway-restricted SMAD protein phosphorylation
heart valve development
embryonic pattern specification
ventricular septum development
cardiac septum morphogenesis
outflow tract morphogenesis
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of ossification
response to estrogen