ZNF335

Entrez Summary: The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008].
UniProt Summary: Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand- dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation. {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:23178126}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Fluorouracil 20μM R00 exp2	-1.91
MS023 7μM R03 exp135	-1.88
Vinblastine 0.2μM R03 exp108	-1.88
CI-1040 9.5μM R08 exp472	-1.81
Amiloride 100μM R08 exp447	-1.73
DABN 20μM R00 exp17	-1.71
Myriocin 25μM R06 exp293	1.71
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.75
Sulforaphane 9μM R08 exp526 no dilution day6	1.78
ABT-702 0.1μM R06 exp260	1.84
2-Methoxyestradiol 0.55μM R07 exp310	1.86
ABT-702 5μM R07 exp318	2
BS-181 20μM R08 exp461	2.03
39°C R06 exp303	2.1
LJH685 5μM R02 exp73	2.1
MSC2530818 10μM R07 exp379	2.19
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.26
D-Fructose 10000μM R06 exp279	2.31
GSK-J5 1.5μM R08 exp484	2.43

Global Fraction of Cell Lines Where Essential: 5/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone H3-K4 trimethylation
positive regulation of neuroblast proliferation
cerebral cortex neuron differentiation
regulation of histone H3-K4 methylation
peptidyl-lysine trimethylation
regulation of neuroblast proliferation
brain morphogenesis
RNA polymerase II core promoter sequence-specific DNA binding
histone H3-K4 methylation
positive regulation of stem cell proliferation
histone methyltransferase complex
positive regulation of neural precursor cell proliferation
regulation of histone methylation
regulation of stem cell proliferation
histone lysine methylation
regulation of neural precursor cell proliferation
peptidyl-lysine methylation
histone methylation
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
protein alkylation
protein methylation
positive regulation of leukocyte proliferation
regulation of histone modification
central nervous system neuron differentiation
regulation of chromatin organization
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
transcription regulatory region DNA binding
regulation of leukocyte proliferation
regulation of gene expression, epigenetic
macromolecule methylation
methylation
peptidyl-lysine modification
regulation of chromosome organization
positive regulation of lymphocyte activation
histone modification
covalent chromatin modification
in utero embryonic development
forebrain development