ABT-702 0.1μM R06 exp260 [The Human Chemical-Genetic Interaction Map Project]

Inhibits adenosine kinase (ADK)

Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor

Compound References

PubChem Name: Adenosine Kinase Inhibitor
Synonyms: N/A
CAS #: 1188890-28-9
PubChem CID: 16760265
IUPAC: 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride
INCHI Name: InChI=1S/C22H19BrN6O.2ClH/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29;;/h1-5,10-13H,6-9H2,(H2,24,26,27,28);2*1H
INCHI Key: OOXNYFKPOPJIOT-UHFFFAOYSA-N
Molecular Weight: 536.2
Canonical SMILES: C1COCCN1C2=NC=C(C=C2)C3=NC4=NC=NC(=C4C(=C3)C5=CC(=CC=C5)Br)N.Cl.Cl
Isomeric SMILES: N/A
Molecular Formula: C22H21BrCl2N6O

Compound Supplier

Supplier Name: Tocris Bioscience
Catalog #: 2372
Lot #: 1B/195137

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H19BrN6O 463.08765; found 463.08744

Dose Response Curve

Platform ID: ABT-702
Min: -17.1478; Max: 50.6783

IC	Concentration (µM)
IC10	N/A
IC20	27.2987
IC30	35.4200
IC40	43.8496
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 06
Dose: 100nM
Days of incubation: 8
Doublings: 7.2
Numbers of reads: 7476948

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
DARS2	-2.53	0.89
HOXD8	-2.34	0.89
CDC26	-2.17	0.89
RNMT	-1.99	0.89
ACBD3	-1.99	0.89
CEP164	-1.99	0.89
SDHA	-1.98	0.89
MRPS25	-1.96	0.89
MAT1A	-1.95	0.89
PHPT1	-1.95	0.89
TRMT2A	-1.92	0.89
BRSK1	-1.92	0.89
SPATA2L	-1.89	0.89
CCDC43	-1.88	0.89
GATSL1	-1.87	0.89
SP100	-1.86	0.89
ROCK2	-1.86	0.89
RTFDC1	-1.85	0.89
TAS2R9	-1.84	0.89
PAX1	-1.84	0.89
IL18RAP	-1.84	0.89
C6orf136	-1.83	0.89
OSTC	-1.82	0.89
THG1L	-1.82	0.89
PCDHB15	-1.82	0.89
TADA1	-1.81	0.89
SAMD9	-1.81	0.89
DPAGT1	-1.80	0.89
DNAJC13	-1.79	0.89
POLM	-1.79	0.89
CCDC150	1.92	0.62
EXOSC8	1.93	0.68
METTL18	1.93	0.62
CDT1	1.93	0.71
MICU2	1.94	0.67
TRIM54	1.95	0.62
AGO3	1.95	0.62
TOR1AIP1	1.96	0.66
STX10	1.96	0.62
UGT2B7	1.97	0.62
AP3M1	1.97	0.62
UBTD2	1.98	0.62
UQCRH	1.99	0.63
DHX38	2.03	0.67
ANP32B	2.04	0.62
ADPRHL2	2.04	0.62
ATG9A	2.05	0.62
RACGAP1	2.07	0.66
ZNF91	2.08	0.62
DBH	2.08	0.62
ANO5	2.10	0.66
DONSON	2.22	0.67
TRAIP	2.25	0.67
HCST	2.27	0.58
ZNF225	2.30	0.58
CABLES1	2.31	0.63
C5AR1	2.31	0.58
VGF	2.38	0.58
C18orf32	2.41	0.67
PSMB4	2.45	0.58

Last modified: 2026/01/15 21:36
by 127.0.0.1