ANP32B

Gene Information

Official Symbol: ANP32B
Official Name: acidic nuclear phosphoprotein 32 family member B
Aliases and Previous Symbols: N/A
Entrez ID: 10541
UniProt: Q92688
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. {ECO:0000250, ECO:0000269|PubMed:20538007}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quercetin 20μM R08 exp517	-2.21
Bisphenol F 50μM R08 exp457	-1.86
UM131593 0.2μM R03 exp106	-1.82
Mubritinib 0.2μM R01 exp48	-1.77
UM0125461 0.74μM R02 exp84	-1.77
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.7
ABT-702 0.1μM R06 exp260	2.04

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12177
Expression level (log2 read counts): 8.3

Expression Distribution

RNA polymerase binding
positive regulation of protein export from nucleus
ventricular system development
regulation of protein export from nucleus
positive regulation of nucleocytoplasmic transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
roof of mouth development
regulation of nucleocytoplasmic transport
nucleosome assembly
histone binding
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
chromatin assembly
positive regulation of cysteine-type endopeptidase activity
positive regulation of intracellular protein transport
chromatin assembly or disassembly
nucleosome organization
positive regulation of endopeptidase activity
DNA packaging
positive regulation of peptidase activity
inner ear development
protein-DNA complex assembly
positive regulation of intracellular transport
regulation of cysteine-type endopeptidase activity involved in apoptotic process
ear development
regulation of intracellular protein transport
regulation of cysteine-type endopeptidase activity
protein-DNA complex subunit organization
DNA conformation change
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of proteolysis
regulation of endopeptidase activity
positive regulation of protein transport
regulation of peptidase activity
positive regulation of establishment of protein localization
vasculature development
cardiovascular system development
regulation of cellular protein localization
sensory organ development
positive regulation of apoptotic process