ADPRHL2

Entrez Summary: N/A
UniProt Summary: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. {ECO:0000269|PubMed:16278211}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
PARP1	0.434
RRM1	0.409

peptidyl-serine ADP-deribosylation
ADP-ribosylserine hydrolase activity
poly(ADP-ribose) glycohydrolase activity
O-acetyl-ADP-ribose deacetylase activity
protein de-ADP-ribosylation
hydrolase activity, hydrolyzing O-glycosyl compounds
cellular response to superoxide
cellular response to oxygen radical
response to superoxide
response to oxygen radical
site of DNA damage
cellular response to reactive oxygen species
response to reactive oxygen species
magnesium ion binding
cellular response to oxidative stress
nuclear body
mitochondrial matrix
response to oxidative stress
DNA repair
response to inorganic substance
DNA metabolic process
cellular response to DNA damage stimulus
cellular response to oxygen-containing compound
mitochondrion
response to oxygen-containing compound
cellular response to stress