ADPRHL2 [The Human Chemical-Genetic Interaction Map Project]

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======= ADPRHL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADPRS
  * **<color #00a2e8>Official Name</color>**: ADP-ribosylserine hydrolase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54936|54936]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX46|Q9NX46]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADPRHL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADPRHL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610624|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. {ECO:0000269|PubMed:16278211}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADP ribosyl GH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-serine ADP-deribosylation|
|ADP-ribosylserine hydrolase activity|
|poly(ADP-ribose) glycohydrolase activity|
|O-acetyl-ADP-ribose deacetylase activity|
|protein de-ADP-ribosylation|
|hydrolase activity, hydrolyzing O-glycosyl compounds|
|cellular response to superoxide|
|cellular response to oxygen radical|
|response to superoxide|
|response to oxygen radical|
|site of DNA damage|
|cellular response to reactive oxygen species|
|response to reactive oxygen species|
|magnesium ion binding|
|cellular response to oxidative stress|
|nuclear body|
|mitochondrial matrix|
|response to oxidative stress|
|DNA repair|
|response to inorganic substance|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular response to oxygen-containing compound|
|mitochondrion|
|response to oxygen-containing compound|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.78|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.01|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.04|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|3.57|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|5.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:parp1|PARP1]]|0.434|
|[[:human genes:r:rrm1|RRM1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2647
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADPRHL2 Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>