OSTC

Entrez Summary: N/A
UniProt Summary: May act as substrate-specific component of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. {ECO:0000269|PubMed:21768116, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 186/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	11/28
blood	1/28
bone	9/26
breast	3/33
central nervous system	10/56
cervix	1/4
colorectal	5/17
esophagus	5/13
fibroblast	0/1
gastric	2/16
kidney	4/21
liver	7/20
lung	14/75
lymphocyte	0/16
ovary	6/26
pancreas	12/24
peripheral nervous system	3/16
plasma cell	11/15
prostate	0/1
skin	6/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	12/22
urinary tract	10/29
uterus	2/5

Expression Distribution

dolichyl-diphosphooligosaccharide-protein glycotransferase activity
oligosaccharyltransferase complex
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
protein N-linked glycosylation
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
peptidyl-amino acid modification
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process