DDT
Gene Information
- Official Symbol: DDT
- Official Name: D-dopachrome tautomerase
- Aliases and Previous Symbols: N/A
- Entrez ID: 1652
- UniProt: P30046
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
Pfam Domains GO Terms
Pfam Domains
| MIF |
GO Terms
| D-dopachrome decarboxylase activity |
| phenylpyruvate tautomerase activity |
| dopachrome isomerase activity |
| negative regulation of macrophage chemotaxis |
| negative regulation of macrophage migration |
| cytokine receptor binding |
| melanin biosynthetic process |
| melanin metabolic process |
| negative regulation of leukocyte chemotaxis |
| secondary metabolite biosynthetic process |
| regulation of macrophage chemotaxis |
| phenol-containing compound biosynthetic process |
| regulation of macrophage migration |
| negative regulation of leukocyte migration |
| pigment biosynthetic process |
| secondary metabolic process |
| negative regulation of chemotaxis |
| pigment metabolic process |
| phenol-containing compound metabolic process |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of leukocyte chemotaxis |
| positive regulation of inflammatory response |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| organic hydroxy compound biosynthetic process |
| regulation of leukocyte migration |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| negative regulation of cell migration |
| negative regulation of cell motility |
| regulation of ERK1 and ERK2 cascade |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| regulation of inflammatory response |
| negative regulation of response to external stimulus |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| organic hydroxy compound metabolic process |
| positive regulation of defense response |
| positive regulation of MAPK cascade |
| positive regulation of response to external stimulus |
| regulation of cytokine production |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of cell migration |
| regulation of cell motility |
| regulation of locomotion |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| aromatic compound biosynthetic process |
| positive regulation of protein modification process |
| organic cyclic compound biosynthetic process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Epothilone-D 0.004 to 0.006μM on day4 R05 exp232 | 2.01 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TCEB3CL2 | 0.523 |
| NOL8 | 0.514 |
| HGC6.3 | 0.503 |
| COPG1 | 0.5 |
| TCEB3C | 0.495 |
| TCEB3CL | 0.491 |
| CHD4 | 0.488 |
| PSMD11 | 0.488 |
| RPS12 | 0.479 |
| PSMB4 | 0.475 |
| UTP3 | 0.469 |
| PSMA6 | 0.467 |
| UPF1 | 0.466 |
| ZNF830 | 0.465 |
| TP53TG3B | 0.459 |
| TP53TG3 | 0.458 |
| KRT2 | 0.458 |
| PSMD1 | 0.458 |
| TP53TG3C | 0.457 |
| TWISTNB | 0.456 |
| FAM160A1 | 0.456 |
| COPA | 0.455 |
| AAMP | 0.452 |
| SLC6A17 | 0.451 |
| COPB1 | 0.45 |
| TOP1MT | 0.449 |
| CBWD3 | 0.447 |
| PSMD3 | 0.444 |
| CACTIN | 0.444 |
| RRP15 | 0.443 |
| MT1E | 0.441 |
| CTAGE4 | 0.44 |
| PDCD11 | 0.44 |
| COL2A1 | 0.437 |
| RPL34 | 0.436 |
| LRR1 | 0.434 |
| AKAP1 | 0.432 |
| NUPL1 | 0.432 |
| TBC1D3G | 0.432 |
| KCTD17 | 0.431 |
| SLC4A1 | 0.43 |
| TICRR | 0.429 |
| GOLGA8O | 0.429 |
| PSMB2 | 0.427 |
| POP7 | 0.427 |
| MCOLN1 | 0.426 |
| ATP6V1C1 | 0.425 |
| PWP2 | 0.424 |
| MED14 | 0.423 |
| HIVEP3 | 0.421 |
| DTL | 0.42 |
| GOLGA6L3 | 0.419 |
| WDR87 | 0.419 |
| SSH2 | 0.416 |
| PAN3 | 0.415 |
| ZFAND5 | 0.414 |
| C1QTNF9B | 0.414 |
| PSMA7 | 0.413 |
| PSMD14 | 0.413 |
| RPS19 | 0.412 |
| TBC1D3H | 0.412 |
| ZNF541 | 0.411 |
| DOCK6 | 0.41 |
| ATXN1 | 0.41 |
| CTAGE9 | 0.41 |
| EBNA1BP2 | 0.409 |
| PAF1 | 0.409 |
| CLN6 | 0.408 |
| PSMC2 | 0.408 |
| SEC13 | 0.408 |
| RBBP5 | 0.407 |
| DHX38 | 0.407 |
| HAP1 | 0.406 |
| CDC45 | 0.405 |
| NPIPB5 | 0.404 |
| RILPL2 | 0.403 |
| NARFL | 0.402 |
| TAGLN | 0.402 |
| PRMT8 | 0.402 |
| NUP153 | 0.402 |
| IGFN1 | 0.402 |
| MYB | 0.401 |
| NOP16 | 0.401 |
| PSMD2 | 0.4 |
| CBWD5 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A
| Tissue | Fraction Of Cell Lines Where Essential |
|---|
Essentiality in NALM6
- Essentiality Rank: 2045
- Expression level (log2 read counts): 5.01
Expression Distribution
DDT Expression in NALM6 Cells: 5.01
