DDT [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DDT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDT
  * **<color #00a2e8>Official Name</color>**: D-dopachrome tautomerase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1652|1652]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30046|P30046]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602750|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|D-dopachrome decarboxylase activity|
|phenylpyruvate tautomerase activity|
|dopachrome isomerase activity|
|negative regulation of macrophage chemotaxis|
|negative regulation of macrophage migration|
|cytokine receptor binding|
|melanin biosynthetic process|
|melanin metabolic process|
|negative regulation of leukocyte chemotaxis|
|secondary metabolite biosynthetic process|
|regulation of macrophage chemotaxis|
|phenol-containing compound biosynthetic process|
|regulation of macrophage migration|
|negative regulation of leukocyte migration|
|pigment biosynthetic process|
|secondary metabolic process|
|negative regulation of chemotaxis|
|pigment metabolic process|
|phenol-containing compound metabolic process|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of leukocyte chemotaxis|
|positive regulation of inflammatory response|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|organic hydroxy compound biosynthetic process|
|regulation of leukocyte migration|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|organic hydroxy compound metabolic process|
|positive regulation of defense response|
|positive regulation of MAPK cascade|
|positive regulation of response to external stimulus|
|regulation of cytokine production|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|aromatic compound biosynthetic process|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.523|
|[[:human genes:n:nol8|NOL8]]|0.514|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.503|
|[[:human genes:c:copg1|COPG1]]|0.5|
|[[:human genes:t:tceb3c|TCEB3C]]|0.495|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.491|
|[[:human genes:c:chd4|CHD4]]|0.488|
|[[:human genes:p:psmd11|PSMD11]]|0.488|
|[[:human genes:r:rps12|RPS12]]|0.479|
|[[:human genes:p:psmb4|PSMB4]]|0.475|
|[[:human genes:u:utp3|UTP3]]|0.469|
|[[:human genes:p:psma6|PSMA6]]|0.467|
|[[:human genes:u:upf1|UPF1]]|0.466|
|[[:human genes:z:znf830|ZNF830]]|0.465|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.459|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.458|
|[[:human genes:k:krt2|KRT2]]|0.458|
|[[:human genes:p:psmd1|PSMD1]]|0.458|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.457|
|[[:human genes:t:twistnb|TWISTNB]]|0.456|
|[[:human genes:f:fam160a1|FAM160A1]]|0.456|
|[[:human genes:c:copa|COPA]]|0.455|
|[[:human genes:a:aamp|AAMP]]|0.452|
|[[:human genes:s:slc6a17|SLC6A17]]|0.451|
|[[:human genes:c:copb1|COPB1]]|0.45|
|[[:human genes:t:top1mt|TOP1MT]]|0.449|
|[[:human genes:c:cbwd3|CBWD3]]|0.447|
|[[:human genes:p:psmd3|PSMD3]]|0.444|
|[[:human genes:c:cactin|CACTIN]]|0.444|
|[[:human genes:r:rrp15|RRP15]]|0.443|
|[[:human genes:m:mt1e|MT1E]]|0.441|
|[[:human genes:c:ctage4|CTAGE4]]|0.44|
|[[:human genes:p:pdcd11|PDCD11]]|0.44|
|[[:human genes:c:col2a1|COL2A1]]|0.437|
|[[:human genes:r:rpl34|RPL34]]|0.436|
|[[:human genes:l:lrr1|LRR1]]|0.434|
|[[:human genes:a:akap1|AKAP1]]|0.432|
|[[:human genes:n:nupl1|NUPL1]]|0.432|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.432|
|[[:human genes:k:kctd17|KCTD17]]|0.431|
|[[:human genes:s:slc4a1|SLC4A1]]|0.43|
|[[:human genes:t:ticrr|TICRR]]|0.429|
|[[:human genes:g:golga8o|GOLGA8O]]|0.429|
|[[:human genes:p:psmb2|PSMB2]]|0.427|
|[[:human genes:p:pop7|POP7]]|0.427|
|[[:human genes:m:mcoln1|MCOLN1]]|0.426|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.425|
|[[:human genes:p:pwp2|PWP2]]|0.424|
|[[:human genes:m:med14|MED14]]|0.423|
|[[:human genes:h:hivep3|HIVEP3]]|0.421|
|[[:human genes:d:dtl|DTL]]|0.42|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.419|
|[[:human genes:w:wdr87|WDR87]]|0.419|
|[[:human genes:s:ssh2|SSH2]]|0.416|
|[[:human genes:p:pan3|PAN3]]|0.415|
|[[:human genes:z:zfand5|ZFAND5]]|0.414|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.414|
|[[:human genes:p:psma7|PSMA7]]|0.413|
|[[:human genes:p:psmd14|PSMD14]]|0.413|
|[[:human genes:r:rps19|RPS19]]|0.412|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.412|
|[[:human genes:z:znf541|ZNF541]]|0.411|
|[[:human genes:d:dock6|DOCK6]]|0.41|
|[[:human genes:a:atxn1|ATXN1]]|0.41|
|[[:human genes:c:ctage9|CTAGE9]]|0.41|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.409|
|[[:human genes:p:paf1|PAF1]]|0.409|
|[[:human genes:c:cln6|CLN6]]|0.408|
|[[:human genes:p:psmc2|PSMC2]]|0.408|
|[[:human genes:s:sec13|SEC13]]|0.408|
|[[:human genes:r:rbbp5|RBBP5]]|0.407|
|[[:human genes:d:dhx38|DHX38]]|0.407|
|[[:human genes:h:hap1|HAP1]]|0.406|
|[[:human genes:c:cdc45|CDC45]]|0.405|
|[[:human genes:n:npipb5|NPIPB5]]|0.404|
|[[:human genes:r:rilpl2|RILPL2]]|0.403|
|[[:human genes:n:narfl|NARFL]]|0.402|
|[[:human genes:t:tagln|TAGLN]]|0.402|
|[[:human genes:p:prmt8|PRMT8]]|0.402|
|[[:human genes:n:nup153|NUP153]]|0.402|
|[[:human genes:i:igfn1|IGFN1]]|0.402|
|[[:human genes:m:myb|MYB]]|0.401|
|[[:human genes:n:nop16|NOP16]]|0.401|
|[[:human genes:p:psmd2|PSMD2]]|0.4|
|[[:human genes:c:cbwd5|CBWD5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2045
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDT Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>