MYB

Gene Information

Official Symbol: MYB
Official Name: MYB proto-oncogene, transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 4602
UniProt: P10242
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK2206 4μM R08 exp504	-3.15
Etoposide 1μM R00 exp19	-2.07
Vitamin-D3 40μM R08 exp536	-1.85
PU-H71 1μM R08 exp515	-1.77
ABT-702 5μM R07 exp318	1.71
Demecolcine 0.03μM R05 exp228	1.73
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.75
Apcin 25μM plus proTAME 2μM R04 exp177	1.76
Parthenolide 2.5μM R05 exp238	1.77
BRD2 inhibitor II 20μM R07 exp341	1.79
Alpha-Amanitin 0.5μM R00 exp5	1.8
Adefovir 20μM R07 exp332	1.82
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.84
Aminopterin 0.005μM R07 exp335	1.97
IU1-C 25μM R04 exp183	1.97
UM0131023 0.05μM R05 exp248	2.09
Zebularine 20μM R07 exp423	2.1
MLN-4924 0.2μM R00 exp21	2.13
proTAME 5μM R04 exp187	2.24
Pifithrin-alpha 20μM R07 exp390	2.25
TRAIL 5ng/ml R00 exp35	2.27
Nifuroxazide 5μM R03 exp102	2.6

Gene	Correlation
PSMB4	0.581
CHD4	0.548
TBC1D3G	0.531
TCEB3CL2	0.521
TBC1D3F	0.511
TBC1D3	0.51
RPS2	0.509
TCEB3CL	0.509
POLR2D	0.509
TBC1D3H	0.508
TBC1D3I	0.505
TBC1D3E	0.505
TBC1D3K	0.504
TBC1D3L	0.504
CBWD3	0.497
TCEB3C	0.495
PSMA6	0.492
TBC1D3C	0.492
RRM1	0.489
SUPT6H	0.488
EXOSC5	0.488
CBWD5	0.486
RPS5	0.483
PSMD11	0.482
POLR2J3	0.481
TAF1	0.48
PSMC6	0.48
PSMB1	0.477
VPS54	0.477
UPF1	0.474
GOLGA6L6	0.472
PSMB2	0.471
PSMA7	0.467
CBWD6	0.465
KCTD17	0.465
AAMP	0.463
PSMC1	0.462
PRIM1	0.457
COPG1	0.457
BRD2	0.453
COPB2	0.453
NOP16	0.453
TOP1MT	0.451
CACTIN	0.448
RRP15	0.448
NPIPB5	0.448
TSPY1	0.448
IGFN1	0.446
RPS12	0.445
SUPT5H	0.444
SF3A1	0.443
PSMD1	0.442
SYT9	0.441
FAM25B	0.441
KIF3C	0.44
HGC6.3	0.439
ZNF106	0.439
CCNA2	0.439
NPIPB8	0.437
RPS7	0.436
LAD1	0.436
STIL	0.435
TWISTNB	0.435
OGFR	0.435
POLA1	0.434
RPL35	0.433
POLA2	0.431
ANKLE2	0.43
DDX3X	0.429
PSMC2	0.429
GOLGA6L1	0.429
ATP6V1A	0.427
ATP6V1C1	0.427
NBPF10	0.427
COL2A1	0.426
ARCN1	0.426
HIST2H2BF	0.424
PWP2	0.424
RPS11	0.424
ORC1	0.423
RPS28	0.423
PPAN	0.422
TFIP11	0.422
MED15	0.421
VASN	0.421
CDC45	0.421
NUP98	0.418
MED14	0.418
NOL10	0.418
RAD21	0.417
RPL30	0.416
DDTL	0.416
HAP1	0.416
RBBP5	0.416
CEP192	0.415
NARFL	0.413
CDC6	0.412
SMG1	0.412
BYSL	0.411
MYO1H	0.41
AQR	0.41
AATF	0.41
ATXN1	0.41
COX7A2L	0.408
TRAPPC11	0.408
WAPAL	0.408
MED29	0.408
PBXIP1	0.407
PAF1	0.405
MRS2	0.405
FBXO5	0.405
UTP3	0.405
COPE	0.404
PI4KB	0.403
VPS52	0.403
EP300	0.403
RPS9	0.402
GOLGA6L3	0.402
CCDC94	0.402
SLC4A1	0.401
SSRP1	0.401
DDT	0.401
RIOK2	0.401
RPL9	0.4
NOL9	0.4
MYT1L	0.4
COPZ1	0.4
SLC23A3	0.4
RNF121	0.4
COPA	0.4

Global Fraction of Cell Lines Where Essential: 37/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	23/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 486
Expression level (log2 read counts): 7.68

Expression Distribution

Wos2
Myb DNA-binding
Cmyb C

regulation of hepatic stellate cell proliferation
positive regulation of hepatic stellate cell proliferation
positive regulation of testosterone secretion
regulation of testosterone secretion
positive regulation of hepatic stellate cell activation
regulation of hepatic stellate cell activation
positive regulation of histone H3-K9 methylation
positive regulation of glial cell proliferation
positive regulation of histone H3-K4 methylation
positive regulation of transforming growth factor beta production
positive regulation of T-helper cell differentiation
regulation of histone H3-K9 methylation
positive regulation of collagen biosynthetic process
positive regulation of collagen metabolic process
regulation of histone H3-K4 methylation
positive regulation of CD4-positive, alpha-beta T cell differentiation
regulation of glial cell proliferation
regulation of T-helper cell differentiation
positive regulation of CD4-positive, alpha-beta T cell activation
regulation of collagen biosynthetic process
regulation of transforming growth factor beta production
positive regulation of histone methylation
regulation of collagen metabolic process
positive regulation of alpha-beta T cell differentiation
regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of fibroblast proliferation
positive regulation of neuron apoptotic process
regulation of CD4-positive, alpha-beta T cell activation
positive regulation of alpha-beta T cell activation
positive regulation of lipid transport
regulation of alpha-beta T cell differentiation
regulation of histone methylation
positive regulation of gliogenesis
cellular response to retinoic acid
cellular response to hydrogen peroxide
regulation of hematopoietic stem cell differentiation
positive regulation of lipid localization
regulation of fibroblast proliferation
positive regulation of T cell differentiation
positive regulation of smooth muscle cell proliferation