RPS28

Entrez Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CR131-b 0.005μM R08 exp474	-2.23
RK-33 8μM R08 exp518	-2.22
Sulforaphane 9μM R08 exp525	-2.21
Trientine 500μM R08 exp534	-2.04
Hippuristanol 0.12μM R08 exp488	-1.92
CFI-400945 25μM R08 exp469	-1.85
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.7
Isonicotinamide 500μM R03 exp129	1.74
Chloramphenicol 20μM R00 exp13	1.75
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.78
Colchicine 0.009μM R05 exp215	1.79
CHIR-124 0.04μM R06 exp272	1.82
proTAME 5μM R04 exp187	1.82
Glyphosate 1000μM R06 exp283	1.83
Nicotinate 1000μM R03 exp140	1.83
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.87
L-74142 5μM R03 exp131	1.88
TRAIL 5ng/ml R00 exp35	1.91
GSK-J4 1μM R07 exp362	1.96
UNC2400 2μM R03 exp156	2
A-395 10μM R05 exp218	2.02
DABN 2μM R00 exp16	2.13
MS094 2μM R03 exp136	2.13
Q15 1 to 2μM on day4 R04 exp164	2.17
Nocodazole 0.02μM R00 exp23	2.39
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	2.52
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	2.59
Rapamycin 1μM R00 exp29	2.73
Rifampicin 10μM R00 exp32	3.33

Global Fraction of Cell Lines Where Essential: 727/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/26
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	72/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution

cytoplasmic side of rough endoplasmic reticulum membrane
small ribosomal subunit
ribosomal small subunit assembly
polysomal ribosome
cytosolic small ribosomal subunit
maturation of SSU-rRNA
ribosome assembly
ribosomal small subunit biogenesis
cytoplasmic translation
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
rRNA processing
mRNA catabolic process
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA catabolic process
establishment of protein localization to membrane
ribosome biogenesis
protein targeting
nucleobase-containing compound catabolic process
translation
ncRNA processing
peptide biosynthetic process
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process