CTDP1

Gene Information

Official Symbol: CTDP1
Official Name: CTD phosphatase subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 9150
UniProt: Q9Y5B0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
UniProt Summary: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epothilone-B 0.0015μM R05 exp231	-2.05
Dorsomorphin 5μM R07 exp357	-1.85
QNZ 0.01μM R08 exp439	-1.74
Rotenone 0.07μM R08 exp431	-1.72
MLN-4924 2μM R00 exp22	-1.7

Global Fraction of Cell Lines Where Essential: 485/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	23/28
blood	21/28
bone	14/25
breast	26/33
central nervous system	34/56
cervix	3/4
colorectal	14/17
esophagus	9/13
fibroblast	0/1
gastric	10/15
kidney	13/21
liver	10/20
lung	41/75
lymphocyte	10/14
ovary	23/26
pancreas	18/24
peripheral nervous system	13/16
plasma cell	10/15
prostate	0/1
skin	17/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	14/22
urinary tract	17/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 1484
Expression level (log2 read counts): 5.67

Expression Distribution

Gene	Correlation
POLR2J3	0.447
RPS28	0.404

NIF
FCP1 C
PTCB-BRCT

TFIIF-class transcription factor complex binding
dephosphorylation of RNA polymerase II C-terminal domain
RNA polymerase II CTD heptapeptide repeat phosphatase activity
Tat protein binding
negative regulation of cell growth involved in cardiac muscle cell development
exit from mitosis
negative regulation of cardiac muscle cell differentiation
positive regulation by host of viral transcription
regulation of cell growth involved in cardiac muscle cell development
negative regulation of cardiocyte differentiation
negative regulation of heart growth
negative regulation of cardiac muscle tissue growth
spindle midzone
negative regulation of cardiac muscle hypertrophy
negative regulation of muscle hypertrophy
negative regulation of organ growth
negative regulation of cardiac muscle tissue development
regulation of cardiac muscle cell differentiation
negative regulation of striated muscle cell differentiation
positive regulation of viral transcription
phosphoprotein phosphatase activity
negative regulation of striated muscle tissue development
negative regulation of muscle organ development
regulation of cardiocyte differentiation
negative regulation of muscle tissue development
negative regulation of muscle cell differentiation
regulation of cardiac muscle hypertrophy
regulation of cardiac muscle tissue growth
regulation of muscle hypertrophy
regulation of heart growth
regulation of viral transcription
modification by host of symbiont morphology or physiology
transcription elongation from RNA polymerase II promoter
interaction with symbiont
regulation of cardiac muscle tissue development
regulation of muscle adaptation
DNA-templated transcription, elongation
regulation of organ growth
regulation of striated muscle cell differentiation
negative regulation of developmental growth