TBC1D3E

Gene Information

Official Symbol: TBC1D3E
Official Name: TBC1 domain family member 3E
Aliases and Previous Symbols: N/A
Entrez ID: 102723859
UniProt: A0A087X179
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R08 exp439	-2.38
SNS-032 15μM R08 exp443	-2.32
Phenformin 20μM R05 exp212	-2.22
Doxorubicin 0.02μM R08 exp478	-1.77
TIC10 10μM R08 exp532	-1.77
ONC212 0.15μM R08 exp513	-1.75
RK-33 8μM R08 exp518	-1.72
CCCP 0.1μM R00 exp10	1.71
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.73
Cyclosporin-A 0.8μM R07 exp347	1.74
GSK-J5 1.5μM R08 exp484	1.78
Epigallocatechin gallate 20μM R05 exp230	1.8
Apcin 50 to 100μM on day4 R04 exp176	1.84
Rifampicin 1μM R00 exp31	1.88
IU1-47 25μM R04 exp182	1.96
Hypoxia 5%O2 R04 exp191	1.97
Golgicide-A 2μM R03 exp121	1.97
Metformin 40μM R03 exp132	2.06
Cidofovir 10μM R07 exp345	2.1
GSK-LSD1 10μM R03 exp123	2.12
GSK343 3μM R03 exp124	2.12
RO-3306 3 to 4μM on day4 R04 exp165	2.16
WNT3A 44ng/ml R08 exp537	2.33
3-Bromopyruvate 7μM R04 exp175	2.61
Cisplatin 0.35μM R06 exp273	2.69
proTAME 5μM R04 exp187	2.84

Gene	Correlation
POLR2J3	0.583
TCEB3CL2	0.579
RPS2	0.561
TFIP11	0.558
PSMA6	0.558
VASN	0.553
TCEB3CL	0.553
TCEB3C	0.546
C1QTNF9B	0.54
DTL	0.535
TIMELESS	0.525
PSMD3	0.524
C14orf93	0.523
RBBP5	0.516
CHD4	0.515
RPS28	0.511
LRR1	0.51
FAM160A1	0.509
DDTL	0.506
MYB	0.505
CDC73	0.503
AQR	0.502
KCTD17	0.502
PWP2	0.502
CCDC94	0.502
MT1E	0.501
RPL35	0.5
CBWD5	0.495
CBWD3	0.494
TICRR	0.494
PSMB1	0.493
PSMC1	0.492
WDR87	0.49
SYT9	0.489
SUPT6H	0.487
RRN3	0.487
CACTIN	0.487
SUPT5H	0.486
TPX2	0.485
HIST2H3C	0.482
EXOSC8	0.482
HIST2H3A	0.482
RBM39	0.481
ANKLE2	0.481
OGFR	0.48
CGB2	0.48
RPS5	0.479
SF3A1	0.479
HIST2H2BF	0.479
MDM2	0.479
RPL6	0.479
TYMS	0.478
TRAIP	0.478
ZNF655	0.478
PSMB4	0.477
RPL34	0.476
RPS12	0.475
EXOSC9	0.473
DDX56	0.473
MCOLN1	0.471
FCN2	0.47
NARFL	0.47
DNM2	0.469
RAD51	0.468
NFATC4	0.468
MYO1H	0.467
UTP3	0.467
BYSL	0.466
NOP16	0.465
RIOK2	0.465
PRPF8	0.464
PSMB2	0.464
NUPL1	0.464
PAN3	0.464
SEC13	0.463
ORC1	0.463
MED17	0.463
KIF3C	0.462
RRP7A	0.462
NOL10	0.462
POLA1	0.462
CKAP5	0.462
PSAP	0.461
ZNF574	0.459
RPS7	0.459
CDC6	0.459
EXOSC5	0.459
CBWD6	0.459
NOL12	0.458
COPE	0.458
COPB1	0.457
UPF1	0.457
COL2A1	0.457
RFXANK	0.456
AKIRIN2	0.455
ZFAND5	0.455
PSMA7	0.455
SSH2	0.454
PSMD1	0.454
NPIPB5	0.454
PDE4DIP	0.454
PSMD11	0.453
EXOSC3	0.453
CHAF1A	0.452
POLA2	0.451
PBXIP1	0.451
PSMD7	0.451
TSPY1	0.451
KRT78	0.45
RPS14	0.45
CCNA2	0.45
PCF11	0.45
MADCAM1	0.45
SLC4A1	0.45
TRIM52	0.449
CACNA1A	0.448
ZNF106	0.447
RPL30	0.446
NPIPB8	0.445
SULT1A3	0.445
GOLGA6B	0.445
SULT1A4	0.444
IGFN1	0.443
SLC6A17	0.442
MED29	0.442
HAP1	0.442
PPFIA4	0.442
KPNB1	0.442
EBNA1BP2	0.441
MYO18A	0.441
RPS11	0.441
BCL2L1	0.44
GOLGA6L4	0.44
RRP15	0.439
ORC6	0.439
SFPQ	0.439
MED14	0.438
RPS19BP1	0.438
HIST1H2BE	0.438
MYT1L	0.438
PSMC6	0.437
TOP1MT	0.437
PAN2	0.437
PAF1	0.437
AAMP	0.437
RPS20	0.436
NAPA	0.436
ARCN1	0.436
NBPF10	0.436
PSMD14	0.435
DNTTIP2	0.435
ACSF2	0.435
COPG1	0.433
RNF4	0.432
RPA2	0.432
CTR9	0.431
S1PR4	0.431
HIVEP3	0.431
CHMP2A	0.43
GOLGA6L3	0.43
POLE	0.429
RPL9	0.429
CCDC64B	0.428
SEL1L	0.427
TERF2	0.427
ADD2	0.426
MSH5	0.425
INTS6	0.425
NUP107	0.424
PSMC2	0.424
CMYA5	0.424
XYLT2	0.424
CASC3	0.424
POLR1A	0.424
NDC80	0.423
CEP192	0.422
NUP62	0.422
FBXW9	0.422
FAM20A	0.422
ISCU	0.422
SRRT	0.421
FAM86B2	0.421
COPZ1	0.421
WDR75	0.419
SNRPA1	0.419
PSMB3	0.419
CDCA3	0.418
GOLGA8O	0.418
WDR90	0.417
TSPY2	0.417
POLR2A	0.417
LAD1	0.417
TUBA8	0.417
ANKLE1	0.417
PSMD2	0.417
SCAF1	0.417
RPS9	0.416
TWISTNB	0.416
COPA	0.416
CDC45	0.416
SART1	0.415
ZNF219	0.415
PSMD8	0.414
ELMOD3	0.414
ATP13A1	0.414
RPS19	0.412
FBXL19	0.412
C2orf27B	0.412
TSPY8	0.412
C3orf17	0.412
AATF	0.412
NUP43	0.412
NUP153	0.412
PLA2G4F	0.411
RAD21	0.411
AKT1S1	0.41
CNPY3	0.41
GID4	0.41
PSMD13	0.409
RPL14	0.408
SMG1	0.408
COX7A2L	0.408
NUP54	0.408
ATP6V1C1	0.408
RPS10	0.407
GAR1	0.407
PPM1D	0.407
FAM25B	0.406
UBE2Q2L	0.406
PRPF19	0.406
PALB2	0.406
IK	0.405
PSMC5	0.405
MYH7B	0.405
XAB2	0.404
EGR2	0.404
EXD1	0.404
SMG7	0.404
ADRA1D	0.404
MYH2	0.404
NUP85	0.403
VPS28	0.403
MMS22L	0.402
ART5	0.402
CCDC116	0.401
UBALD1	0.401
RPS3A	0.401
UTP20	0.4
OR10G3	0.4
CPLX3	0.4
NUP205	0.4

Essentiality in NALM6

Essentiality Rank: 546
Expression level (log2 read counts): -0.45

Expression Distribution

activation of GTPase activity
Rab GTPase binding
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
positive regulation of hydrolase activity
intracellular protein transport
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport