MADCAM1

Gene Information
  • Official Symbol: MADCAM1
  • Official Name: mucosal vascular addressin cell adhesion molecule 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 8174
  • UniProt: Q13477
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 2330
  • Expression level (log2 read counts): -1.11

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1