TBC1D3

Gene Information

Official Symbol: TBC1D3
Official Name: TBC1 domain family member 3
Aliases and Previous Symbols: N/A
Entrez ID: 729873
UniProt: Q8IZP1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. {ECO:0000269|PubMed:12359748}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 15μM R08 exp443	-1.82
Phenformin 20μM R05 exp212	-1.81
IU1-47 25μM R04 exp182	1.71
RO-3306 3 to 4μM on day4 R04 exp165	1.81
Ribavirin 10μM R01 exp52	1.83
Caffeine 2600μM R08 exp463	1.93
Nifuroxazide 1μM R01 exp51	2.01

Gene	Correlation
RPS2	0.578
TCEB3CL2	0.574
C1QTNF9B	0.567
VASN	0.563
PSMA6	0.563
KCTD17	0.561
TCEB3CL	0.559
TCEB3C	0.554
TFIP11	0.551
CHD4	0.538
LRR1	0.538
RRN3	0.533
COL2A1	0.525
POLR2J3	0.523
CBWD3	0.521
TIMELESS	0.52
WDR87	0.519
DTL	0.518
PSMB2	0.516
MYB	0.51
FAM160A1	0.51
C14orf93	0.508
SUPT5H	0.507
NOL10	0.507
NUPL1	0.505
SYT9	0.504
CCNA2	0.501
UTP3	0.501
CBWD5	0.501
RAD51	0.5
RPS12	0.498
PPFIA4	0.498
CCDC94	0.497
PSMD3	0.497
PSMC1	0.495
EXOSC8	0.495
TICRR	0.495
TWISTNB	0.494
RPS28	0.49
CBWD6	0.489
RPL6	0.489
GOLGA6A	0.489
RPS7	0.487
AQR	0.484
RPS19BP1	0.484
CDC73	0.484
IK	0.484
PSMB1	0.483
CDC6	0.482
ANKLE2	0.482
OGFR	0.481
POLA2	0.48
EXOSC5	0.48
TSPY1	0.48
GOLGA6B	0.479
RBBP5	0.479
SLC4A1	0.478
TPX2	0.478
ORC6	0.477
RRP7A	0.477
KRT78	0.476
PDE4DIP	0.476
RPS5	0.476
MT1E	0.475
COPE	0.475
CKAP5	0.474
UPF1	0.474
RPL35	0.474
NBPF10	0.474
FCN2	0.473
EXOSC3	0.472
PSMA7	0.471
CHAF1A	0.471
MYO1H	0.471
ELMOD3	0.47
CGB2	0.47
POLR2A	0.47
CCDC64B	0.469
POLR2D	0.469
HIVEP3	0.469
DDX56	0.469
DDTL	0.468
ZFAND5	0.468
TRAIP	0.468
PSMB4	0.468
EXOSC9	0.468
EBNA1BP2	0.466
PBXIP1	0.466
DNTTIP2	0.466
NPIPB8	0.466
RPS20	0.466
RPL9	0.466
BYSL	0.465
CACTIN	0.464
FBXW9	0.464
HAP1	0.463
SAP30BP	0.463
MYH7B	0.463
TRIM52	0.463
ZNF655	0.462
NFATC4	0.461
ORC1	0.461
TYMS	0.461
AAMP	0.461
MED17	0.459
RFXANK	0.457
RIOK2	0.457
MMS22L	0.457
PCF11	0.457
RPL34	0.456
NARFL	0.455
AATF	0.455
ADD2	0.455
POLE	0.455
S1PR4	0.455
POLR1A	0.453
HIST2H2BF	0.452
GOLGA8O	0.452
NAPA	0.452
ZNF106	0.452
RAD21	0.451
NPIPB5	0.451
TONSL	0.45
IGFN1	0.45
MYT1L	0.449
STIL	0.449
PSMD8	0.449
AKIRIN2	0.449
PAN2	0.448
NOL12	0.448
PWP2	0.448
MADCAM1	0.448
MED14	0.447
PAN3	0.447
NOP16	0.446
SLC6A17	0.446
ATP6V1C1	0.446
SEC13	0.446
MCOLN1	0.445
SSH2	0.444
TERF2	0.444
PRPF8	0.443
HIST2H3A	0.443
RRP15	0.443
HIST2H3C	0.442
SART1	0.442
MDM2	0.442
TUBA8	0.442
TSG101	0.441
EXD1	0.441
SUPT6H	0.441
CMYA5	0.441
MSH5	0.44
SNRPA1	0.439
PSMD7	0.439
C2orf27B	0.439
TTK	0.438
EGR2	0.437
MED29	0.437
PSMD11	0.437
RPS14	0.437
PSMB3	0.435
MYO18A	0.435
CDC45	0.435
ANKLE1	0.435
ZNF219	0.435
PSMC6	0.435
CDCA3	0.435
DHX38	0.434
KIF3C	0.434
ACSF2	0.433
PSMD1	0.433
POLA1	0.432
ZNF830	0.431
RBM39	0.431
CEP192	0.43
CACNA1A	0.43
SEL1L	0.43
COPB1	0.429
NUP62	0.429
RPL14	0.429
HIST1H2BE	0.429
RPS3A	0.428
COX7A2L	0.427
NUP43	0.426
WDR75	0.426
AKT1S1	0.426
CHMP2A	0.426
PSMD2	0.425
VPS28	0.425
PLXNB3	0.425
CNOT1	0.424
PLK4	0.424
SH3BP1	0.423
BAGE3	0.422
BAGE5	0.421
BAGE2	0.421
BAGE4	0.421
BAGE	0.421
PLA2G4F	0.42
DNM2	0.419
FAM20A	0.419
GID4	0.419
MYH2	0.418
SULT1A3	0.418
SULT1A4	0.417
SMG1	0.417
POLR2J	0.416
INTS6	0.416
MFSD12	0.416
XYLT2	0.415
NUP54	0.415
TOPBP1	0.415
ZNF574	0.415
CLN6	0.414
UTP20	0.414
SF3A1	0.414
RPS9	0.414
ARHGEF35	0.414
CNPY3	0.413
PRIM1	0.413
NUP133	0.413
DISP2	0.413
OR10G3	0.412
NDC80	0.412
FAM25B	0.412
CCDC116	0.412
BCL2L1	0.412
TSPY8	0.411
RPL7L1	0.411
MBTD1	0.411
XAB2	0.411
ARCN1	0.411
MCF2L	0.41
WDR43	0.41
TGM5	0.41
RPL30	0.41
GOLGA6L3	0.409
PRPF19	0.408
RPA2	0.408
NUP85	0.408
COPG1	0.408
KPNB1	0.408
NUP153	0.407
RPS19	0.407
RPS11	0.407
TSPY2	0.406
WAPAL	0.406
CDK9	0.406
LAD1	0.406
GOLGA6L4	0.406
COPA	0.406
USPL1	0.406
SMG7	0.405
CHCHD3	0.405
MYLK3	0.405
DOCK6	0.405
ADRM1	0.404
DIEXF	0.403
ITGA2B	0.403
SMTN	0.403
SKIV2L2	0.403
GAR1	0.402
USP36	0.401
BRIX1	0.401
PSMC5	0.401
HNRNPC	0.4
CDH24	0.4
TP53TG3D	0.4

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1246
Expression level (log2 read counts): -0.88

Expression Distribution

regulation of cilium assembly
activation of GTPase activity
Rab GTPase binding
early endosome membrane
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
positive regulation of hydrolase activity
regulation of cellular component biogenesis
intracellular protein transport
regulation of hydrolase activity
regulation of organelle organization
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport