GAR1

Entrez Summary: N/A
UniProt Summary: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (“psi”) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:10757788, ECO:0000269|PubMed:15044956}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.7
Chloramphenicol 2μM R00 exp12	1.72
Rucaparib 6.5μM R08 exp520	1.75
Rifampicin 10μM R00 exp32	1.76
Aphidicolin 0.04μM R06 exp263	1.77
Chloramphenicol 20μM R00 exp13	1.8
Celastrol 0.12μM R05 exp225	1.83
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.85
NFN1 1μM R03 exp100	1.87
Alpha-Amanitin 0.5μM R00 exp5	1.91
Betulinic acid 10 to 15μM on day4 R05 exp222	1.91
Cycloheximide 0.2μM R00 exp15	1.91
Ethanol 0.003 R08 exp437	2.07
Doxycycline 10μM R00 exp18	2.09
Colchicine 0.009μM R05 exp215	2.12

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	3/20
lung	1/75
lymphocyte	0/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Expression Distribution

snoRNA guided rRNA pseudouridine synthesis
box H/ACA telomerase RNP complex
box H/ACA scaRNP complex
box H/ACA snoRNA binding
box H/ACA snoRNP complex
rRNA pseudouridine synthesis
pseudouridine synthesis
telomerase holoenzyme complex
telomerase RNA binding
telomere maintenance via telomerase
telomere maintenance via telomere lengthening
RNA-dependent DNA biosynthetic process
rRNA modification
telomere maintenance
telomere organization
DNA biosynthetic process
nuclear chromosome, telomeric region
fibrillar center
RNA modification
rRNA processing
rRNA metabolic process
ribosome biogenesis
anatomical structure homeostasis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
DNA metabolic process
RNA processing
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
RNA binding
cellular nitrogen compound biosynthetic process
homeostatic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression