GAR1 [The Human Chemical-Genetic Interaction Map Project]

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======= GAR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAR1
  * **<color #00a2e8>Official Name</color>**: GAR1 ribonucleoprotein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54433|54433]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NY12|Q9NY12]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606468|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:10757788, ECO:0000269|PubMed:15044956}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gar1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snoRNA guided rRNA pseudouridine synthesis|
|box H/ACA telomerase RNP complex|
|box H/ACA scaRNP complex|
|box H/ACA snoRNA binding|
|box H/ACA snoRNP complex|
|rRNA pseudouridine synthesis|
|pseudouridine synthesis|
|telomerase holoenzyme complex|
|telomerase RNA binding|
|telomere maintenance via telomerase|
|telomere maintenance via telomere lengthening|
|RNA-dependent DNA biosynthetic process|
|rRNA modification|
|telomere maintenance|
|telomere organization|
|DNA biosynthetic process|
|nuclear chromosome, telomeric region|
|fibrillar center|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|anatomical structure homeostasis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|DNA metabolic process|
|RNA processing|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.7|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.72|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.75|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.76|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.77|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.8|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.83|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.85|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.87|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.91|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.91|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.91|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.07|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.09|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfip11|TFIP11]]|0.557|
|[[:human genes:o:orc1|ORC1]]|0.525|
|[[:human genes:c:cope|COPE]]|0.51|
|[[:human genes:p:prim1|PRIM1]]|0.509|
|[[:human genes:t:ticrr|TICRR]]|0.507|
|[[:human genes:v:vasn|VASN]]|0.504|
|[[:human genes:t:twistnb|TWISTNB]]|0.496|
|[[:human genes:c:copg1|COPG1]]|0.49|
|[[:human genes:t:tyms|TYMS]]|0.484|
|[[:human genes:t:terf2|TERF2]]|0.477|
|[[:human genes:a:aqr|AQR]]|0.474|
|[[:human genes:i:ik|IK]]|0.469|
|[[:human genes:s:supt5h|SUPT5H]]|0.468|
|[[:human genes:c:cdc73|CDC73]]|0.466|
|[[:human genes:d:dtl|DTL]]|0.459|
|[[:human genes:p:psmd7|PSMD7]]|0.459|
|[[:human genes:r:rpl37a|RPL37A]]|0.458|
|[[:human genes:s:slc4a1|SLC4A1]]|0.455|
|[[:human genes:c:chaf1a|CHAF1A]]|0.454|
|[[:human genes:k:kctd17|KCTD17]]|0.454|
|[[:human genes:t:tuba8|TUBA8]]|0.452|
|[[:human genes:n:nupl1|NUPL1]]|0.451|
|[[:human genes:s:scaf1|SCAF1]]|0.45|
|[[:human genes:a:ankle1|ANKLE1]]|0.45|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.449|
|[[:human genes:a:acsf2|ACSF2]]|0.448|
|[[:human genes:n:nup160|NUP160]]|0.447|
|[[:human genes:c:c14orf93|C14orf93]]|0.447|
|[[:human genes:s:s1pr4|S1PR4]]|0.445|
|[[:human genes:s:syt9|SYT9]]|0.444|
|[[:human genes:a:aatf|AATF]]|0.443|
|[[:human genes:l:lrr1|LRR1]]|0.443|
|[[:human genes:r:rps19|RPS19]]|0.441|
|[[:human genes:n:narfl|NARFL]]|0.441|
|[[:human genes:c:chmp2a|CHMP2A]]|0.44|
|[[:human genes:s:sf3b5|SF3B5]]|0.434|
|[[:human genes:m:mt1e|MT1E]]|0.433|
|[[:human genes:r:rps12|RPS12]]|0.431|
|[[:human genes:p:psmb2|PSMB2]]|0.431|
|[[:human genes:x:xylt2|XYLT2]]|0.43|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.429|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.429|
|[[:human genes:u:utp3|UTP3]]|0.429|
|[[:human genes:z:znf655|ZNF655]]|0.428|
|[[:human genes:n:nop56|NOP56]]|0.427|
|[[:human genes:p:psmb4|PSMB4]]|0.427|
|[[:human genes:p:psmc2|PSMC2]]|0.426|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.426|
|[[:human genes:u:ubap1|UBAP1]]|0.424|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.424|
|[[:human genes:d:dock6|DOCK6]]|0.423|
|[[:human genes:n:nup93|NUP93]]|0.423|
|[[:human genes:h:hivep3|HIVEP3]]|0.422|
|[[:human genes:a:aamp|AAMP]]|0.422|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.421|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.421|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.421|
|[[:human genes:p:pan3|PAN3]]|0.421|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.421|
|[[:human genes:s:sf3a2|SF3A2]]|0.42|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.42|
|[[:human genes:r:rpsa|RPSA]]|0.42|
|[[:human genes:s:shpk|SHPK]]|0.42|
|[[:human genes:t:tceb3c|TCEB3C]]|0.419|
|[[:human genes:f:fam160a1|FAM160A1]]|0.418|
|[[:human genes:a:atxn1|ATXN1]]|0.418|
|[[:human genes:d:ddtl|DDTL]]|0.418|
|[[:human genes:e:egr2|EGR2]]|0.418|
|[[:human genes:c:chd4|CHD4]]|0.417|
|[[:human genes:n:napa|NAPA]]|0.416|
|[[:human genes:c:copb1|COPB1]]|0.416|
|[[:human genes:p:psmb1|PSMB1]]|0.416|
|[[:human genes:v:vps28|VPS28]]|0.414|
|[[:human genes:k:kif3c|KIF3C]]|0.414|
|[[:human genes:z:znf830|ZNF830]]|0.413|
|[[:human genes:i:iscu|ISCU]]|0.413|
|[[:human genes:c:ccna2|CCNA2]]|0.413|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.412|
|[[:human genes:i:ints5|INTS5]]|0.411|
|[[:human genes:p:psmd11|PSMD11]]|0.409|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.407|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.407|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.407|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.407|
|[[:human genes:c:cbwd3|CBWD3]]|0.407|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.407|
|[[:human genes:c:ckap5|CKAP5]]|0.407|
|[[:human genes:r:rpl14|RPL14]]|0.406|
|[[:human genes:p:psmc5|PSMC5]]|0.405|
|[[:human genes:a:arcn1|ARCN1]]|0.404|
|[[:human genes:c:copa|COPA]]|0.404|
|[[:human genes:a:akirin2|AKIRIN2]]|0.404|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.402|
|[[:human genes:n:nup133|NUP133]]|0.402|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.402|
|[[:human genes:n:nsf|NSF]]|0.401|
|[[:human genes:s:sult2b1|SULT2B1]]|0.401|
|[[:human genes:g:golga8o|GOLGA8O]]|0.401|
|[[:human genes:t:tpx2|TPX2]]|0.401|
|[[:human genes:n:nup153|NUP153]]|0.4|
|[[:human genes:r:rbm39|RBM39]]|0.4|
|[[:human genes:e:exosc5|EXOSC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|3/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1251
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAR1 Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>