Aphidicolin 0.04μM R06 exp263
Mechanism of Action
Inhibits DNA polymerases Polα, Polδ, Polϵ and Polζ
- Class / Subclass 1: DNA Damage, Repair and Replication / Replication Inhibitor
- Class / Subclass 2: Cell Cycle / Replication Inhibitor
- Class / Subclass 3: Infectious Disease / Antiviral
Technical Notes
Compound References
- PubChem Name: Aphidicolin
- Synonyms: N/A
- CAS #: 38966-21-1
- PubChem CID: 457964
- IUPAC: (1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
- INCHI Name: InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
- INCHI Key: NOFOAYPPHIUXJR-APNQCZIXSA-N
- Molecular Weight: 338.5
- Canonical SMILES: CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
- Isomeric SMILES: C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
- Molecular Formula: C20H34O4
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: A726260
- Lot #: 1-TSS-153-1
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C20H34O4 361.23493; found 361.23594
Dose Response Curve
- Platform ID: Aphidicolin_A
- Min: 12.3100; Max: 89.3842
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | 0.0187 |
| IC40 | N/A |
| IC50 | 0.0634 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 40nM
- Days of incubation: 8
- Doublings: 6.4
- Numbers of reads: 8228186
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Aphidicolin 0.04μM R06 exp263
