ABCB11

• Official Symbol: ABCB11
• Official Name: ATP binding cassette subfamily B member 11
• Aliases and Previous Symbols: N/A
• Entrez ID: 8647
• UniProt: O95342
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008].
• UniProt Summary: Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 12232
• Expression level (log2 read counts): -6.6

Expression Distribution

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ABCB11 Expression in NALM6 Cells: -6.6