GIPR
Gene Information
- Official Symbol: GIPR
- Official Name: gastric inhibitory polypeptide receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 2696
- UniProt: P48546
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Pfam Domains GO Terms
Pfam Domains
| HRM |
| 7tm 2 |
GO Terms
| gastric inhibitory peptide receptor activity |
| gastric inhibitory peptide signaling pathway |
| desensitization of G protein-coupled receptor signaling pathway |
| negative adaptation of signaling pathway |
| adaptation of signaling pathway |
| positive regulation of cAMP-mediated signaling |
| endocrine pancreas development |
| activation of adenylate cyclase activity |
| G protein-coupled peptide receptor activity |
| peptide hormone binding |
| negative regulation of G protein-coupled receptor signaling pathway |
| response to axon injury |
| regulation of cAMP-mediated signaling |
| pancreas development |
| positive regulation of insulin secretion |
| response to fatty acid |
| positive regulation of peptide hormone secretion |
| endocrine system development |
| positive regulation of hormone secretion |
| transmembrane signaling receptor activity |
| response to glucose |
| response to hexose |
| regulation of G protein-coupled receptor signaling pathway |
| response to monosaccharide |
| response to calcium ion |
| response to carbohydrate |
| regulation of insulin secretion |
| regulation of peptide hormone secretion |
| response to nutrient |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of peptide secretion |
| regulation of cytosolic calcium ion concentration |
| response to acid chemical |
| response to metal ion |
| positive regulation of secretion by cell |
| generation of precursor metabolites and energy |
| positive regulation of protein transport |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| response to nutrient levels |
| response to extracellular stimulus |
| regulation of hormone levels |
| response to inorganic substance |
| cellular metal ion homeostasis |
| response to wounding |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| response to lipid |
| cellular homeostasis |
| positive regulation of transport |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| chemical homeostasis |
| negative regulation of signal transduction |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| response to oxygen-containing compound |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GSK-J4 1.5μM R08 exp441 | 2.07 |
| Aphidicolin 0.04μM R06 exp263 | 2.09 |
| GSK461364A 0.005μM R03 exp125 | 2.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3836
- Expression level (log2 read counts): 2.59
Expression Distribution
GIPR Expression in NALM6 Cells: 2.59
