ADAMTS10
Gene Information
- Official Symbol: ADAMTS10
- Official Name: ADAM metallopeptidase with thrombospondin type 1 motif 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 81794
- UniProt: Q9H324
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008].
- UniProt Summary: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. {ECO:0000269|PubMed:21402694}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7031
- Expression level (log2 read counts): 2.25
ADAMTS10 Expression in NALM6 Cells: 2.25
