CCT2
Gene Information
- Official Symbol: CCT2
- Official Name: chaperonin containing TCP1 subunit 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10576
- UniProt: P78371
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.
Pfam Domains GO Terms
Pfam Domains
| Cpn60 TCP1 |
GO Terms
| chaperone mediated protein folding independent of cofactor |
| RNA localization to Cajal body |
| scaRNA localization to Cajal body |
| RNA localization to nucleus |
| zona pellucida receptor complex |
| positive regulation of protein localization to Cajal body |
| regulation of protein localization to Cajal body |
| positive regulation of establishment of protein localization to telomere |
| regulation of establishment of protein localization to telomere |
| chaperonin-containing T-complex |
| regulation of establishment of protein localization to chromosome |
| positive regulation of protein localization to chromosome, telomeric region |
| regulation of protein localization to chromosome, telomeric region |
| positive regulation of telomerase RNA localization to Cajal body |
| chaperone-mediated protein complex assembly |
| regulation of telomerase RNA localization to Cajal body |
| protein folding chaperone |
| positive regulation of telomere maintenance via telomerase |
| binding of sperm to zona pellucida |
| positive regulation of telomerase activity |
| positive regulation of telomere maintenance via telomere lengthening |
| de novo posttranslational protein folding |
| toxin transport |
| de novo protein folding |
| positive regulation of telomere maintenance |
| sperm-egg recognition |
| regulation of telomerase activity |
| regulation of telomere maintenance via telomerase |
| chaperone-mediated protein folding |
| regulation of telomere maintenance via telomere lengthening |
| positive regulation of DNA biosynthetic process |
| cell-cell recognition |
| cell body |
| positive regulation of protein localization to nucleus |
| regulation of telomere maintenance |
| azurophil granule lumen |
| regulation of DNA biosynthetic process |
| regulation of protein localization to nucleus |
| unfolded protein binding |
| single fertilization |
| fertilization |
| positive regulation of chromosome organization |
| protein stabilization |
| positive regulation of DNA metabolic process |
| RNA localization |
| protein folding |
| cell recognition |
| regulation of protein stability |
| ubiquitin protein ligase binding |
| microtubule |
| positive regulation of cellular protein localization |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| positive regulation of establishment of protein localization |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of cellular protein localization |
| myeloid leukocyte activation |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| positive regulation of transferase activity |
| regulated exocytosis |
| regulation of establishment of protein localization |
| leukocyte mediated immunity |
| exocytosis |
| sexual reproduction |
| cellular protein-containing complex assembly |
| regulation of cellular localization |
| leukocyte activation |
| regulation of transferase activity |
| multi-organism reproductive process |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| ATP binding |
| protein-containing complex assembly |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.517 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 692/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 26/28 |
| bone | 26/26 |
| breast | 31/33 |
| central nervous system | 51/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 19/21 |
| liver | 16/20 |
| lung | 71/75 |
| lymphocyte | 15/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 13/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 455
- Expression level (log2 read counts): 8.77
Expression Distribution
CCT2 Expression in NALM6 Cells: 8.77
