RNF220

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658). {ECO:0000250|UniProtKB:Q6PDX6, ECO:0000269|PubMed:25266658}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aphidicolin 0.04μM R06 exp263	-1.99
UM0011500 5μM R05 exp245	-1.73
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.74
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.23

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein autoubiquitination
positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
regulation of canonical Wnt signaling pathway
regulation of Wnt signaling pathway
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling