RNF6

Gene Information

Official Symbol: RNF6
Official Name: ring finger protein 6
Aliases and Previous Symbols: N/A
Entrez ID: 6049
UniProt: Q9Y252
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008].
UniProt Summary: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269|PubMed:19345326}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nutlin-3A 1.6μM R06 exp294	-1.86
DABN racemic mixture R03 exp93	-1.83
Epothilone-B 0.0015μM R05 exp231	1.71
Rifampicin 30μM R08 exp430	1.87
Aphidicolin 0.04μM R06 exp263	1.88

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13451
Expression level (log2 read counts): 5.43

Expression Distribution

zf-C3HC4
zf-rbx1

protein K27-linked ubiquitination
protein K6-linked ubiquitination
regulation of androgen receptor signaling pathway
negative regulation of axon extension
androgen receptor binding
protein K48-linked ubiquitination
negative regulation of axonogenesis
regulation of intracellular steroid hormone receptor signaling pathway
regulation of axon extension
negative regulation of cell morphogenesis involved in differentiation
PML body
negative regulation of developmental growth
regulation of extent of cell growth
negative regulation of neuron projection development
negative regulation of cell projection organization
regulation of cell size
negative regulation of cell growth
regulation of axonogenesis
ubiquitin protein ligase activity
negative regulation of neuron differentiation
nuclear membrane
negative regulation of growth
ubiquitin-protein transferase activity
negative regulation of neurogenesis
axon
protein polyubiquitination
regulation of cell morphogenesis involved in differentiation
negative regulation of nervous system development
regulation of developmental growth
negative regulation of cell development
regulation of cellular component size
regulation of cell growth
regulation of cell morphogenesis
regulation of neuron projection development
regulation of anatomical structure size
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process