CLTB

Entrez Summary: N/A
UniProt Summary: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

postsynaptic endocytic zone cytoplasmic component
clathrin vesicle coat
presynaptic endocytic zone membrane
clathrin coat
clathrin coat of trans-Golgi network vesicle
clathrin coat of coated pit
clathrin heavy chain binding
clathrin coat assembly
clathrin-dependent endocytosis
clathrin-coated endocytic vesicle
peptide binding
ciliary membrane
synaptic vesicle membrane
trans-Golgi network
structural molecule activity
receptor-mediated endocytosis
endocytosis
import into cell
intracellular membrane-bounded organelle
cellular protein-containing complex assembly
membrane organization
intracellular protein transport
protein transport
intracellular transport
peptide transport
protein-containing complex assembly
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
protein-containing complex subunit organization
vesicle-mediated transport