CLTB [The Human Chemical-Genetic Interaction Map Project]

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======= CLTB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLTB
  * **<color #00a2e8>Official Name</color>**: clathrin light chain B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1212|1212]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09497|P09497]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLTB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLTB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Clathrin lg ch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic endocytic zone cytoplasmic component|
|clathrin vesicle coat|
|presynaptic endocytic zone membrane|
|clathrin coat|
|clathrin coat of trans-Golgi network vesicle|
|clathrin coat of coated pit|
|clathrin heavy chain binding|
|clathrin coat assembly|
|clathrin-dependent endocytosis|
|clathrin-coated endocytic vesicle|
|peptide binding|
|ciliary membrane|
|synaptic vesicle membrane|
|trans-Golgi network|
|structural molecule activity|
|receptor-mediated endocytosis|
|endocytosis|
|import into cell|
|intracellular membrane-bounded organelle|
|cellular protein-containing complex assembly|
|membrane organization|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.2|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-2.08|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.8|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.71|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.85|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12492
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLTB Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>