SHPK

Entrez Summary: The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as a modulator of macrophage activation through control of glucose metabolism. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sedoheptulokinase activity
cellular response to interleukin-13
response to interleukin-13
pentose-phosphate shunt, non-oxidative branch
pentose-phosphate shunt
NADPH regeneration
glucose 6-phosphate metabolic process
NADP metabolic process
cellular response to interleukin-4
response to interleukin-4
regulation of macrophage activation
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
response to lipopolysaccharide
response to molecule of bacterial origin
regulation of inflammatory response
generation of precursor metabolites and energy
carbohydrate metabolic process
cellular response to lipid
regulation of leukocyte activation
regulation of cell activation
response to bacterium
regulation of defense response
response to lipid
organophosphate metabolic process
oxidation-reduction process
cellular response to cytokine stimulus
carbohydrate derivative metabolic process
cellular response to oxygen-containing compound
regulation of response to external stimulus
response to cytokine
phosphorylation
response to other organism
response to external biotic stimulus
response to biotic stimulus
regulation of response to stress
ATP binding
response to oxygen-containing compound
regulation of immune system process