S1PR4

Entrez Summary: N/A
UniProt Summary: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sphingosine-1-phosphate receptor activity
sphingosine-1-phosphate receptor signaling pathway
sphingolipid mediated signaling pathway
activation of phospholipase C activity
positive regulation of phospholipase C activity
regulation of phospholipase C activity
positive regulation of phospholipase activity
positive regulation of lipase activity
regulation of phospholipase activity
regulation of lipase activity
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP-mediated signaling
lipid binding
cyclic-nucleotide-mediated signaling
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
positive regulation of hydrolase activity
ion homeostasis
cellular homeostasis
chemical homeostasis
mitochondrion
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
integral component of plasma membrane
positive regulation of catalytic activity