S1PR4 [The Human Chemical-Genetic Interaction Map Project]

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======= S1PR4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: S1PR4
  * **<color #00a2e8>Official Name</color>**: sphingosine-1-phosphate receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8698|8698]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95977|O95977]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=S1PR4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20S1PR4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603751|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sphingosine-1-phosphate receptor activity|
|sphingosine-1-phosphate receptor signaling pathway|
|sphingolipid mediated signaling pathway|
|activation of phospholipase C activity|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|positive regulation of phospholipase activity|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|regulation of lipase activity|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|lipid binding|
|cyclic-nucleotide-mediated signaling|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cellular homeostasis|
|chemical homeostasis|
|mitochondrion|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of molecular function|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.535|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.529|
|[[:human genes:m:madcam1|MADCAM1]]|0.529|
|[[:human genes:p:prim1|PRIM1]]|0.513|
|[[:human genes:c:c14orf93|C14orf93]]|0.512|
|[[:human genes:s:ssh2|SSH2]]|0.511|
|[[:human genes:c:chmp2a|CHMP2A]]|0.509|
|[[:human genes:m:mt1e|MT1E]]|0.505|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.5|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.499|
|[[:human genes:r:rps12|RPS12]]|0.496|
|[[:human genes:n:nupl1|NUPL1]]|0.494|
|[[:human genes:t:tfip11|TFIP11]]|0.49|
|[[:human genes:p:psmc6|PSMC6]]|0.489|
|[[:human genes:g:golga8o|GOLGA8O]]|0.489|
|[[:human genes:a:aqr|AQR]]|0.488|
|[[:human genes:c:cdc73|CDC73]]|0.488|
|[[:human genes:o:orc1|ORC1]]|0.485|
|[[:human genes:p:psmb1|PSMB1]]|0.483|
|[[:human genes:r:rps9|RPS9]]|0.481|
|[[:human genes:p:psap|PSAP]]|0.477|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.476|
|[[:human genes:p:psmd2|PSMD2]]|0.472|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.471|
|[[:human genes:k:kctd17|KCTD17]]|0.471|
|[[:human genes:a:ahctf1|AHCTF1]]|0.471|
|[[:human genes:d:ddtl|DDTL]]|0.47|
|[[:human genes:v:vasn|VASN]]|0.468|
|[[:human genes:p:psmb4|PSMB4]]|0.467|
|[[:human genes:t:twistnb|TWISTNB]]|0.466|
|[[:human genes:s:scaf1|SCAF1]]|0.463|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.463|
|[[:human genes:w:wdr87|WDR87]]|0.462|
|[[:human genes:d:dtl|DTL]]|0.46|
|[[:human genes:p:psmd1|PSMD1]]|0.46|
|[[:human genes:f:fbl|FBL]]|0.457|
|[[:human genes:c:chd4|CHD4]]|0.457|
|[[:human genes:h:hivep3|HIVEP3]]|0.457|
|[[:human genes:z:znf106|ZNF106]]|0.455|
|[[:human genes:s:snrpa1|SNRPA1]]|0.455|
|[[:human genes:p:psma6|PSMA6]]|0.455|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.455|
|[[:human genes:t:tceb3c|TCEB3C]]|0.454|
|[[:human genes:t:trim52|TRIM52]]|0.452|
|[[:human genes:p:psma7|PSMA7]]|0.449|
|[[:human genes:t:tpx2|TPX2]]|0.446|
|[[:human genes:i:igfn1|IGFN1]]|0.446|
|[[:human genes:r:riok2|RIOK2]]|0.445|
|[[:human genes:g:gar1|GAR1]]|0.445|
|[[:human genes:c:cbwd3|CBWD3]]|0.444|
|[[:human genes:r:rps2|RPS2]]|0.443|
|[[:human genes:c:cactin|CACTIN]]|0.441|
|[[:human genes:r:rbbp5|RBBP5]]|0.441|
|[[:human genes:n:nop16|NOP16]]|0.441|
|[[:human genes:t:tspy8|TSPY8]]|0.439|
|[[:human genes:n:nup54|NUP54]]|0.439|
|[[:human genes:a:akirin2|AKIRIN2]]|0.438|
|[[:human genes:a:adamtsl4|ADAMTSL4]]|0.437|
|[[:human genes:c:cbwd5|CBWD5]]|0.437|
|[[:human genes:r:rad51|RAD51]]|0.435|
|[[:human genes:m:mdm2|MDM2]]|0.435|
|[[:human genes:r:rps7|RPS7]]|0.434|
|[[:human genes:p:pole|POLE]]|0.434|
|[[:human genes:r:rrn3|RRN3]]|0.434|
|[[:human genes:a:ankle1|ANKLE1]]|0.434|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.433|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.432|
|[[:human genes:n:ndc1|NDC1]]|0.432|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.431|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.431|
|[[:human genes:m:myo18a|MYO18A]]|0.431|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.431|
|[[:human genes:g:gon4l|GON4L]]|0.431|
|[[:human genes:r:rpl6|RPL6]]|0.431|
|[[:human genes:m:myo1h|MYO1H]]|0.43|
|[[:human genes:r:rps5|RPS5]]|0.43|
|[[:human genes:s:smg1|SMG1]]|0.428|
|[[:human genes:p:psmc1|PSMC1]]|0.427|
|[[:human genes:i:ints5|INTS5]]|0.427|
|[[:human genes:s:supt6h|SUPT6H]]|0.426|
|[[:human genes:m:med29|MED29]]|0.426|
|[[:human genes:r:rpl35|RPL35]]|0.425|
|[[:human genes:p:polr2j3|POLR2J3]]|0.425|
|[[:human genes:c:ccna2|CCNA2]]|0.425|
|[[:human genes:c:ckap5|CKAP5]]|0.425|
|[[:human genes:p:psmd3|PSMD3]]|0.425|
|[[:human genes:r:rad21|RAD21]]|0.424|
|[[:human genes:a:art5|ART5]]|0.423|
|[[:human genes:p:plk4|PLK4]]|0.422|
|[[:human genes:p:ppfia4|PPFIA4]]|0.422|
|[[:human genes:c:chaf1a|CHAF1A]]|0.421|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.421|
|[[:human genes:e:egr2|EGR2]]|0.421|
|[[:human genes:s:sfpq|SFPQ]]|0.42|
|[[:human genes:u:upf1|UPF1]]|0.419|
|[[:human genes:p:pcf11|PCF11]]|0.418|
|[[:human genes:c:cdca3|CDCA3]]|0.418|
|[[:human genes:s:smg7|SMG7]]|0.418|
|[[:human genes:c:cdc6|CDC6]]|0.418|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.417|
|[[:human genes:p:pan2|PAN2]]|0.416|
|[[:human genes:f:fzd9|FZD9]]|0.415|
|[[:human genes:z:znf830|ZNF830]]|0.413|
|[[:human genes:a:atxn1|ATXN1]]|0.413|
|[[:human genes:c:cope|COPE]]|0.413|
|[[:human genes:b:bage3|BAGE3]]|0.412|
|[[:human genes:b:bage4|BAGE4]]|0.412|
|[[:human genes:m:myh7b|MYH7B]]|0.412|
|[[:human genes:b:bage2|BAGE2]]|0.412|
|[[:human genes:b:bage5|BAGE5]]|0.411|
|[[:human genes:r:rps28|RPS28]]|0.411|
|[[:human genes:c:copg1|COPG1]]|0.411|
|[[:human genes:b:bage|BAGE]]|0.411|
|[[:human genes:s:shpk|SHPK]]|0.411|
|[[:human genes:p:psmc2|PSMC2]]|0.41|
|[[:human genes:l:loc643669|LOC643669]]|0.41|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.41|
|[[:human genes:s:syt9|SYT9]]|0.409|
|[[:human genes:f:fam86b2|FAM86B2]]|0.409|
|[[:human genes:s:slc4a1|SLC4A1]]|0.408|
|[[:human genes:r:rpsa|RPSA]]|0.408|
|[[:human genes:s:srrm2|SRRM2]]|0.408|
|[[:human genes:n:ndc80|NDC80]]|0.407|
|[[:human genes:f:fam20a|FAM20A]]|0.406|
|[[:human genes:w:wdr46|WDR46]]|0.406|
|[[:human genes:m:med12|MED12]]|0.406|
|[[:human genes:z:zfand5|ZFAND5]]|0.406|
|[[:human genes:c:ccdc116|CCDC116]]|0.405|
|[[:human genes:p:psmd11|PSMD11]]|0.405|
|[[:human genes:h:hap1|HAP1]]|0.405|
|[[:human genes:s:slc38a7|SLC38A7]]|0.404|
|[[:human genes:p:polr2f|POLR2F]]|0.404|
|[[:human genes:o:ogfr|OGFR]]|0.402|
|[[:human genes:o:orc6|ORC6]]|0.402|
|[[:human genes:a:aatf|AATF]]|0.401|
|[[:human genes:c:cgb2|CGB2]]|0.401|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.401|
|[[:human genes:a:aamp|AAMP]]|0.401|
|[[:human genes:t:ticrr|TICRR]]|0.401|
|[[:human genes:k:kif3c|KIF3C]]|0.4|
|[[:human genes:r:rpl38|RPL38]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2262
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='S1PR4 Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>