SNRPA1

Gene Information

Official Symbol: SNRPA1
Official Name: small nuclear ribonucleoprotein polypeptide A'
Aliases and Previous Symbols: N/A
Entrez ID: 6627
UniProt: P09661
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
PSMB4	0.552
MT1E	0.544
TCEB3CL2	0.536
SUPT5H	0.534
TCEB3C	0.525
ORC6	0.522
CDC6	0.522
C1QTNF9B	0.521
C14orf93	0.519
ATP6V1C1	0.517
NDC1	0.517
TCEB3CL	0.512
HIST1H2BE	0.511
RRN3	0.507
XYLT2	0.506
CBWD3	0.505
POLR2J3	0.504
AQR	0.503
NPIPB5	0.503
CHAF1A	0.502
RAD51	0.501
VASN	0.5
ACSF2	0.498
DTL	0.498
PSMD1	0.497
TBC1D3F	0.496
TFIP11	0.496
UPF1	0.495
CDC73	0.494
EIF4A3	0.493
ZNF655	0.493
TBC1D3H	0.491
CBWD6	0.49
TBC1D3G	0.489
CCNA2	0.484
RPS9	0.484
AHCTF1	0.484
CBWD5	0.483
GOLGA6L3	0.481
RRP15	0.48
COPG1	0.479
RPL35	0.478
CWC22	0.477
NARFL	0.476
NUPL1	0.474
COPE	0.474
CHD4	0.473
RAD21	0.473
STIL	0.472
NUP160	0.472
MYO1H	0.469
SEC13	0.468
CDCA3	0.467
HIST2H2BF	0.467
PSMC1	0.467
SSH2	0.466
ISCU	0.465
POLE	0.463
PSMC6	0.462
EXOSC5	0.461
PSMD6	0.461
PSMA6	0.46
RPS2	0.459
NPIPB3	0.457
RPS19BP1	0.456
HIST2H3A	0.456
HIST2H3C	0.456
S1PR4	0.455
GOLGA8O	0.454
INTS5	0.454
PSMB2	0.453
PAF1	0.453
COPB1	0.451
DISP2	0.451
AAAS	0.449
PRIM1	0.449
UBE2Q2L	0.448
SLC4A1	0.448
DDTL	0.448
TICRR	0.446
PSMD3	0.446
UTP3	0.445
NUFIP2	0.445
SUPT6H	0.445
AAMP	0.445
ATP13A1	0.444
TUBA8	0.444
TBC1D3C	0.444
IGFN1	0.444
RPS12	0.444
ZNF106	0.444
CKAP5	0.443
PSMD2	0.443
WDR87	0.441
SF3A1	0.44
RPSA	0.439
TBC1D3	0.439
PAN3	0.438
LAD1	0.437
SAP30BP	0.436
GOLGA8J	0.436
HAP1	0.436
ORC1	0.436
OGFR	0.436
PSMD11	0.435
COX8A	0.433
CCDC94	0.433
POLA2	0.432
CCDC64B	0.432
WDR43	0.432
RPS28	0.432
PSMC2	0.431
TP53TG3D	0.43
PRMT8	0.43
NUP54	0.429
PSMC5	0.429
CACTIN	0.429
RBM39	0.428
GOLGA8H	0.428
TRIM52	0.428
EXOSC3	0.428
PSMA7	0.428
MSH5	0.426
IK	0.426
URB2	0.426
RRP7A	0.426
C2orf27B	0.426
RPL34	0.425
NAPA	0.424
PPFIA4	0.424
PLA2G4F	0.423
MED17	0.423
POLR2F	0.422
NUP133	0.421
ZNF574	0.42
FAM160A1	0.42
TBC1D3I	0.42
PWP2	0.42
PAN2	0.419
RBBP5	0.419
FCN2	0.419
TBC1D3E	0.419
FBXW9	0.418
TBC1D3L	0.418
TBC1D3K	0.418
SF3B2	0.418
CDH24	0.417
TSG101	0.417
PLK1	0.417
MCF2L	0.416
TPX2	0.416
XAB2	0.415
MYT1L	0.415
ADRA1D	0.414
VPS28	0.414
CTR9	0.414
TP53TG3C	0.414
TP53TG3B	0.414
LRR1	0.414
TP53TG3	0.414
TSPY1	0.413
INTS6	0.412
RPS19	0.412
POLA1	0.411
VPS54	0.411
SYT9	0.411
KRT78	0.411
SF3A2	0.41
PIGS	0.41
KCTD17	0.409
COPA	0.408
SRRM2	0.407
CDC45	0.406
ARCN1	0.406
NUP155	0.405
TYMS	0.405
NUP153	0.405
PSMD8	0.405
KIAA1211	0.405
GOLGA6L4	0.404
MMS22L	0.404
CGB2	0.404
PHF2	0.404
DNTTIP2	0.403
COX7A2L	0.403
SF3B5	0.402
PSMA1	0.402
DDX56	0.402
BRD2	0.402
NUP85	0.401
KPNB1	0.401
DIDO1	0.401
RPS3A	0.4
KRT5	0.4
NUP205	0.4
PLK4	0.4
HIVEP3	0.4
GID4	0.4

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 808
Expression level (log2 read counts): 6.7

Expression Distribution

U2 snRNA binding
small nuclear ribonucleoprotein complex
U2 snRNP
U2-type catalytic step 2 spliceosome
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
U2-type precatalytic spliceosome
catalytic step 2 spliceosome
spliceosomal complex
nuclear body
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
spermatogenesis
male gamete generation
cytokine-mediated signaling pathway
gamete generation
mRNA metabolic process
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
RNA processing
multi-organism reproductive process
cellular response to cytokine stimulus
response to cytokine
RNA binding
reproductive process
reproduction
RNA metabolic process
gene expression