FBXW9 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: FBXW9
Official Name: F-box and WD repeat domain containing 9
Aliases and Previous Symbols: N/A
Entrez ID: 84261
UniProt: Q5XUX1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.1μM R03 exp94	-2.14
Mubritinib 0.2μM R02 exp65	-1.8
Tanespimycin 14μM R08 exp527	-1.73
Daidzin 10μM R06 exp280	1.75
CVT-10216 0.1μM R06 exp278	1.83
Cyclosporin-A 0.8μM R07 exp347	1.86

Gene	Correlation
PCF11	0.514
NUPL1	0.512
C14orf93	0.497
CHD4	0.488
TBC1D3F	0.485
TFIP11	0.481
TBC1D3G	0.476
ORC1	0.471
TBC1D3H	0.467
TBC1D3	0.464
PSMB4	0.463
MDM2	0.462
RAD51	0.462
SUPT6H	0.461
HNRNPC	0.456
ANKLE2	0.454
CBWD5	0.452
DTL	0.451
DNTTIP2	0.447
TBC1D3C	0.446
CACTIN	0.445
PSMD3	0.445
SSH2	0.445
CBWD3	0.444
PSMB2	0.443
PSMC6	0.439
RIOK2	0.437
RPL35	0.432
TCEB3C	0.431
CCDC64B	0.428
CHAF1A	0.428
ZFAND5	0.428
UTP20	0.427
FAM25B	0.427
MT1E	0.427
GPX4	0.426
RPS19BP1	0.426
GOLGA6L3	0.425
PIGS	0.425
ORC6	0.425
TCEB3CL2	0.424
TCEB3CL	0.423
TSPY1	0.423
GOLGA6L4	0.422
TBC1D3K	0.422
TBC1D3L	0.422
PSMD1	0.422
TBC1D3E	0.422
TBC1D3I	0.422
CDC6	0.421
NUP85	0.421
RAD21	0.421
RBM39	0.42
SMG1	0.42
VASN	0.419
TSG101	0.419
COPA	0.418
TICRR	0.418
SNRPA1	0.418
LAD1	0.418
PSMB1	0.417
PSMA6	0.417
MORC2	0.416
RPS28	0.415
IK	0.415
MED17	0.414
PLK4	0.413
GOLGA6A	0.413
ZNF655	0.412
OR10G3	0.412
RANBP2	0.411
RPL4	0.411
RPS12	0.409
AQR	0.409
UTP3	0.407
CBWD6	0.406
XYLT2	0.406
HIST1H2BE	0.406
NOL10	0.405
PAF1	0.403
POLE	0.403
SLC4A1	0.403
DISP2	0.402
RPL6	0.402
RPL34	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2243
Expression level (log2 read counts): 2.83

Expression Distribution

Last modified: 2025/12/10 20:19
by 127.0.0.1