FBXW9 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXW9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXW9
  * **<color #00a2e8>Official Name</color>**: F-box and WD repeat domain containing 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84261|84261]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5XUX1|Q5XUX1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXW9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXW9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609074|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PeBoW complex|
|preribosome, large subunit precursor|
|protein polyubiquitination|
|post-translational protein modification|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.14|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.8|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.73|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.75|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.83|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pcf11|PCF11]]|0.514|
|[[:human genes:n:nupl1|NUPL1]]|0.512|
|[[:human genes:c:c14orf93|C14orf93]]|0.497|
|[[:human genes:c:chd4|CHD4]]|0.488|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.485|
|[[:human genes:t:tfip11|TFIP11]]|0.481|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.476|
|[[:human genes:o:orc1|ORC1]]|0.471|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.467|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.464|
|[[:human genes:p:psmb4|PSMB4]]|0.463|
|[[:human genes:m:mdm2|MDM2]]|0.462|
|[[:human genes:r:rad51|RAD51]]|0.462|
|[[:human genes:s:supt6h|SUPT6H]]|0.461|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.456|
|[[:human genes:a:ankle2|ANKLE2]]|0.454|
|[[:human genes:c:cbwd5|CBWD5]]|0.452|
|[[:human genes:d:dtl|DTL]]|0.451|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.447|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.446|
|[[:human genes:c:cactin|CACTIN]]|0.445|
|[[:human genes:p:psmd3|PSMD3]]|0.445|
|[[:human genes:s:ssh2|SSH2]]|0.445|
|[[:human genes:c:cbwd3|CBWD3]]|0.444|
|[[:human genes:p:psmb2|PSMB2]]|0.443|
|[[:human genes:p:psmc6|PSMC6]]|0.439|
|[[:human genes:r:riok2|RIOK2]]|0.437|
|[[:human genes:r:rpl35|RPL35]]|0.432|
|[[:human genes:t:tceb3c|TCEB3C]]|0.431|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.428|
|[[:human genes:c:chaf1a|CHAF1A]]|0.428|
|[[:human genes:z:zfand5|ZFAND5]]|0.428|
|[[:human genes:u:utp20|UTP20]]|0.427|
|[[:human genes:f:fam25b|FAM25B]]|0.427|
|[[:human genes:m:mt1e|MT1E]]|0.427|
|[[:human genes:g:gpx4|GPX4]]|0.426|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.426|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.425|
|[[:human genes:p:pigs|PIGS]]|0.425|
|[[:human genes:o:orc6|ORC6]]|0.425|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.424|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.423|
|[[:human genes:t:tspy1|TSPY1]]|0.423|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.422|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.422|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.422|
|[[:human genes:p:psmd1|PSMD1]]|0.422|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.422|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.422|
|[[:human genes:c:cdc6|CDC6]]|0.421|
|[[:human genes:n:nup85|NUP85]]|0.421|
|[[:human genes:r:rad21|RAD21]]|0.421|
|[[:human genes:r:rbm39|RBM39]]|0.42|
|[[:human genes:s:smg1|SMG1]]|0.42|
|[[:human genes:v:vasn|VASN]]|0.419|
|[[:human genes:t:tsg101|TSG101]]|0.419|
|[[:human genes:c:copa|COPA]]|0.418|
|[[:human genes:t:ticrr|TICRR]]|0.418|
|[[:human genes:s:snrpa1|SNRPA1]]|0.418|
|[[:human genes:l:lad1|LAD1]]|0.418|
|[[:human genes:p:psmb1|PSMB1]]|0.417|
|[[:human genes:p:psma6|PSMA6]]|0.417|
|[[:human genes:m:morc2|MORC2]]|0.416|
|[[:human genes:r:rps28|RPS28]]|0.415|
|[[:human genes:i:ik|IK]]|0.415|
|[[:human genes:m:med17|MED17]]|0.414|
|[[:human genes:p:plk4|PLK4]]|0.413|
|[[:human genes:g:golga6a|GOLGA6A]]|0.413|
|[[:human genes:z:znf655|ZNF655]]|0.412|
|[[:human genes:o:or10g3|OR10G3]]|0.412|
|[[:human genes:r:ranbp2|RANBP2]]|0.411|
|[[:human genes:r:rpl4|RPL4]]|0.411|
|[[:human genes:r:rps12|RPS12]]|0.409|
|[[:human genes:a:aqr|AQR]]|0.409|
|[[:human genes:u:utp3|UTP3]]|0.407|
|[[:human genes:c:cbwd6|CBWD6]]|0.406|
|[[:human genes:x:xylt2|XYLT2]]|0.406|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.406|
|[[:human genes:n:nol10|NOL10]]|0.405|
|[[:human genes:p:paf1|PAF1]]|0.403|
|[[:human genes:p:pole|POLE]]|0.403|
|[[:human genes:s:slc4a1|SLC4A1]]|0.403|
|[[:human genes:d:disp2|DISP2]]|0.402|
|[[:human genes:r:rpl6|RPL6]]|0.402|
|[[:human genes:r:rpl34|RPL34]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2243
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXW9 Expression in NALM6 Cells: 2.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>