PSMC6

Gene Information

Official Symbol: PSMC6
Official Name: proteasome 26S subunit, ATPase 6
Aliases and Previous Symbols: N/A
Entrez ID: 5706
UniProt: P62333
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SB743921 0.001μM R05 exp244	-2.28
Etoposide 0.3μM R05 exp199	-2.17
Dorsomorphin 5μM R07 exp357	-2.11
6-Thio-2-deoxyguanosine 2μM R06 exp259	-2.02
Artemisinin 50μM R08 exp450	-1.95
BI-2536 0.02μM R03 exp96	-1.73
SNS-032 25μM R07 exp401	-1.72
Ethanol 0.01 R05 exp234	-1.7
Mitomycin-C 0.06μM R08 exp503	-1.7
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.71
A-395N 10μM R05 exp219	1.72
2-Methoxyestradiol 0.2μM R01 exp40	1.73
CCCP 1μM R00 exp11	1.75
Celastrol 0.12μM R05 exp225	1.75
CB-839 10μM R05 exp224	1.79
Doxycycline 10μM R00 exp18	1.8
LB-100 4.1μM R02 exp72	1.82
Wortmannin 5μM R00 exp38	1.82
YM155 0.0002μM R01 exp61	1.82
ABT-702 5μM R07 exp318	1.88
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.9
Taxol 0.002μM R01 exp54	2.51
5-Azacytidine 2μM R07 exp330	2.57

Gene	Correlation
HGC6.3	0.581
PSMB4	0.539
CHD4	0.537
PSMD11	0.535
SMG1	0.531
SUPT6H	0.523
PSMD1	0.52
ZFAND5	0.519
TCEB3CL2	0.517
TBC1D3G	0.514
TCEB3C	0.509
C14orf93	0.508
MT1E	0.504
RPS12	0.5
CDC73	0.499
ORC1	0.499
PAN2	0.498
TCEB3CL	0.496
KPNB1	0.494
DNTTIP2	0.494
PSMC2	0.492
RRP15	0.492
PSMC4	0.492
MYO1H	0.49
PSMD3	0.489
NUPL1	0.489
S1PR4	0.489
TERF2	0.489
NPIPB5	0.488
VASN	0.487
PSMC1	0.486
COPE	0.482
MED14	0.481
MYB	0.48
ZNF106	0.48
PSMA6	0.479
TFIP11	0.478
TBC1D3H	0.478
C1QTNF9B	0.477
WDR43	0.477
RPL35	0.477
PSAP	0.477
PAN3	0.475
DTL	0.473
ANKLE2	0.473
PSMB1	0.473
NOL10	0.472
LAD1	0.472
BCL2L1	0.471
ORC6	0.47
CCNA2	0.469
NUP205	0.468
TBC1D3C	0.467
PSMB2	0.466
PSMD13	0.464
SNRPA1	0.462
RRN3	0.462
POLR1A	0.461
RPS2	0.458
KCTD17	0.454
CCDC94	0.453
SYT9	0.451
COPB1	0.451
HAP1	0.451
PSMD14	0.45
UPF1	0.448
AQR	0.448
PSMA7	0.448
CBWD3	0.446
SSH2	0.445
RPS19BP1	0.445
DISP2	0.444
TBC1D3F	0.444
SMG7	0.444
RNPC3	0.444
MED29	0.442
GOLGA6L6	0.442
CLN6	0.442
DDTL	0.441
FBXW9	0.439
CBWD5	0.439
KIF3C	0.438
RRP7A	0.438
COL2A1	0.438
TYMS	0.438
PPFIA4	0.437
TBC1D3E	0.437
TBC1D3L	0.437
TBC1D3I	0.437
TBC1D3K	0.437
CHMP2A	0.437
NUP107	0.437
RBM39	0.436
CDCA3	0.436
PAF1	0.436
TBC1D3	0.435
OGFR	0.435
SCAF1	0.435
RAD21	0.432
TSPY1	0.432
COPG1	0.432
PSMD6	0.432
TICRR	0.431
CDC45	0.431
POLE	0.431
GPX4	0.43
ZNF830	0.43
NOL8	0.428
CACTIN	0.427
NBPF16	0.426
ITGA2B	0.426
POLR2D	0.426
IGFN1	0.424
HIST1H2BE	0.423
AKIRIN2	0.423
COPA	0.422
RPL14	0.422
EXOSC5	0.422
NDC1	0.422
RPS5	0.421
CKAP5	0.421
RPS28	0.419
NUP98	0.419
EBNA1BP2	0.419
NBPF10	0.418
HIST2H2BF	0.417
TOP1MT	0.417
AHCTF1	0.417
PCF11	0.416
PSMD7	0.416
ATP13A1	0.416
MED17	0.416
RPL6	0.416
ASF1B	0.415
POLR2J3	0.414
NPIPB8	0.412
RBBP5	0.412
NUP54	0.411
PPAN	0.411
PWP2	0.41
HMGCR	0.41
PIGS	0.408
RAN	0.408
POLA1	0.407
PSMD2	0.406
MAT2A	0.405
TRAIP	0.405
OR10G3	0.405
RPS9	0.403
CEP192	0.403
MSH5	0.403
RPSA	0.402
POLA2	0.402
MDM2	0.402
WDR75	0.401
ATXN1	0.401
BAGE2	0.401
LIPE	0.401
EXOSC3	0.401
ADRM1	0.401
BAGE3	0.4
BAGE5	0.4
BAGE	0.4
RPL34	0.4
BAGE4	0.4

Global Fraction of Cell Lines Where Essential: 621/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	24/28
bone	22/26
breast	26/33
central nervous system	50/56
cervix	4/4
colorectal	15/17
esophagus	9/13
fibroblast	1/1
gastric	12/16
kidney	19/21
liver	19/20
lung	67/75
lymphocyte	14/16
ovary	20/26
pancreas	21/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	11/22
urinary tract	20/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 959
Expression level (log2 read counts): 6.86

Expression Distribution

cytosolic proteasome complex
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
proteasome regulatory particle, base subcomplex
regulation of RNA polymerase II transcriptional preinitiation complex assembly
proteasome accessory complex
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, initiation
regulation of transcription initiation from RNA polymerase II promoter
regulation of DNA-templated transcription, initiation
proteasome complex
regulation of cellular amino acid metabolic process
ubiquitin-dependent ERAD pathway
regulation of hematopoietic stem cell differentiation
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of transcription from RNA polymerase II promoter in response to hypoxia
protein binding, bridging
antigen processing and presentation of exogenous peptide antigen via MHC class I
regulation of cellular amine metabolic process
NIK/NF-kappaB signaling
anaphase-promoting complex-dependent catabolic process
regulation of hematopoietic progenitor cell differentiation
negative regulation of G2/M transition of mitotic cell cycle
ERAD pathway
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
interleukin-1-mediated signaling pathway
Wnt signaling pathway, planar cell polarity pathway
antigen processing and presentation of peptide antigen via MHC class I
negative regulation of cell cycle G2/M phase transition
regulation of establishment of planar polarity
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
regulation of stem cell differentiation
tumor necrosis factor-mediated signaling pathway
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
non-canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
regulation of cellular ketone metabolic process
Fc-epsilon receptor signaling pathway
negative regulation of canonical Wnt signaling pathway