CLN6

Entrez Summary: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cycloheximide 0.2μM R00 exp15	2.1
Betulinic acid 10 to 15μM on day4 R05 exp222	2.9
UM0011500 10μM R05 exp246	3.17

locomotion involved in locomotory behavior
lysosomal lumen acidification
regulation of lysosomal lumen pH
ganglioside metabolic process
vacuolar acidification
intracellular pH reduction
pH reduction
lysosome organization
lytic vacuole organization
glycosphingolipid metabolic process
ceramide metabolic process
regulation of intracellular pH
regulation of cellular pH
regulation of pH
glycolipid metabolic process
cellular monovalent inorganic cation homeostasis
liposaccharide metabolic process
cholesterol metabolic process
secondary alcohol metabolic process
vacuole organization
sterol metabolic process
monovalent inorganic cation homeostasis
sphingolipid metabolic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
locomotory behavior
membrane lipid metabolic process
visual perception
sensory perception of light stimulus
steroid metabolic process
endoplasmic reticulum lumen
alcohol metabolic process
positive regulation of proteolysis
organic hydroxy compound metabolic process
behavior
cellular cation homeostasis
cellular ion homeostasis
protein catabolic process
cation homeostasis
inorganic ion homeostasis