RPLP1
Gene Information
- Official Symbol: RPLP1
- Official Name: ribosomal protein lateral stalk subunit P1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6176
- UniProt: P05386
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays an important role in the elongation step of protein synthesis.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal 60s |
GO Terms
| protein kinase activator activity |
| ribonucleoprotein complex binding |
| cytosolic large ribosomal subunit |
| cytoplasmic translation |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| translational elongation |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| RNA catabolic process |
| establishment of protein localization to membrane |
| activation of protein kinase activity |
| regulation of translation |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| regulation of cellular amide metabolic process |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| protein localization to membrane |
| organic cyclic compound catabolic process |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| positive regulation of protein kinase activity |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| regulation of kinase activity |
| cellular macromolecule catabolic process |
| regulation of transferase activity |
| intracellular protein transport |
| positive regulation of protein phosphorylation |
| macromolecule catabolic process |
| positive regulation of phosphorylation |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R05 exp211 | -1.94 |
| GSK461364A 0.1μM R03 exp126 | -1.78 |
| Erlotinib 10μM R05 exp216 | 2.23 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RPS12 | 0.483 |
| CDCA3 | 0.477 |
| SYT9 | 0.471 |
| PSMC1 | 0.465 |
| MT1E | 0.456 |
| PAN2 | 0.455 |
| GOLGA6L1 | 0.452 |
| PSMD3 | 0.452 |
| ATP6V1C1 | 0.444 |
| VASN | 0.437 |
| CLN6 | 0.433 |
| CCNA2 | 0.431 |
| CDC73 | 0.43 |
| TCEB3C | 0.428 |
| PAN3 | 0.427 |
| TYMS | 0.427 |
| SH3BP1 | 0.426 |
| SRFBP1 | 0.424 |
| PPM1D | 0.422 |
| EXOSC3 | 0.418 |
| TPX2 | 0.418 |
| IK | 0.417 |
| HGC6.3 | 0.417 |
| RPLP2 | 0.415 |
| RPL30 | 0.413 |
| NSF | 0.41 |
| AQR | 0.409 |
| C1QTNF9B | 0.408 |
| POLD1 | 0.407 |
| KRT78 | 0.405 |
| ANKLE1 | 0.405 |
| RPS10 | 0.404 |
| CHST3 | 0.404 |
| TBC1D3H | 0.402 |
| RPL26 | 0.401 |
| MADCAM1 | 0.4 |
| EIF2AK4 | 0.4 |
| NUPL1 | 0.4 |
| XYLT2 | 0.4 |
| ACSF2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 373/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 13/28 |
| blood | 13/28 |
| bone | 17/26 |
| breast | 18/33 |
| central nervous system | 35/56 |
| cervix | 4/4 |
| colorectal | 8/17 |
| esophagus | 4/13 |
| fibroblast | 0/1 |
| gastric | 6/16 |
| kidney | 13/21 |
| liver | 14/20 |
| lung | 35/75 |
| lymphocyte | 4/16 |
| ovary | 14/26 |
| pancreas | 5/24 |
| peripheral nervous system | 13/16 |
| plasma cell | 11/15 |
| prostate | 1/1 |
| skin | 11/24 |
| soft tissue | 3/9 |
| thyroid | 2/2 |
| upper aerodigestive | 10/22 |
| urinary tract | 17/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 1763
- Expression level (log2 read counts): 10.13
Expression Distribution
RPLP1 Expression in NALM6 Cells: 10.13
