SYT9

Gene Information

Official Symbol: SYT9
Official Name: synaptotagmin 9
Aliases and Previous Symbols: N/A
Entrez ID: 143425
UniProt: Q86SS6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
TBC1D3G	0.585
TBC1D3H	0.583
TBC1D3F	0.556
TFIP11	0.555
MT1E	0.54
COPE	0.534
SLC4A1	0.519
PSMA6	0.512
NUPL1	0.512
DDTL	0.508
CHD4	0.508
RPS12	0.505
TBC1D3	0.504
TCEB3CL2	0.502
AQR	0.5
SSH2	0.496
TBC1D3C	0.494
SUPT6H	0.49
TBC1D3K	0.489
TBC1D3I	0.489
TBC1D3L	0.489
TBC1D3E	0.489
HAP1	0.487
CDC45	0.487
POLR2J3	0.486
VASN	0.485
UBAP1	0.483
DNTTIP2	0.482
DTL	0.476
FAM25B	0.475
PSMB4	0.474
RRP15	0.474
RPLP1	0.471
ORC1	0.471
CMYA5	0.47
EXOSC5	0.47
RAD21	0.466
CCNA2	0.466
CTAGE4	0.464
RBM39	0.459
ATP6V1C1	0.458
PSMC1	0.458
SF3A2	0.455
RFPL3	0.454
PSMC6	0.451
COPG1	0.451
OR10G3	0.45
RPL34	0.45
GOLGA6A	0.45
CBWD3	0.45
PSMD11	0.45
SEC13	0.449
C1QTNF9B	0.448
CACTIN	0.448
RRN3	0.448
C14orf93	0.447
RBBP5	0.447
TCEB3C	0.446
SH3BP1	0.446
RPS14	0.446
MYO1H	0.444
GAR1	0.444
KRT78	0.443
POLR2D	0.443
ZFAND5	0.442
ORC6	0.442
RPL35	0.441
GOLGA8J	0.441
UTP3	0.441
MYB	0.441
PLK1	0.44
TCEB3CL	0.44
RFXANK	0.44
RAD51	0.439
CCDC94	0.439
AKIRIN2	0.438
SEL1L	0.437
FAM160A1	0.436
CBWD5	0.436
SCAF1	0.435
SNRNP70	0.434
ANKLE1	0.432
SLC25A36	0.431
TICRR	0.431
FCN2	0.43
NAPA	0.43
HIST2H2BF	0.43
ARHGEF35	0.429
NOL8	0.428
HIST1H2BE	0.428
MED14	0.427
EXD1	0.426
CHMP2A	0.425
MADCAM1	0.424
NOL10	0.424
OGFR	0.424
CDC73	0.423
GOLGA8H	0.423
ATP6V1A	0.423
SMG7	0.422
RNF4	0.422
NUP153	0.422
POLR2F	0.422
TUBA8	0.42
PSMD13	0.42
RPL7L1	0.419
COL15A1	0.419
LRR1	0.418
ISCU	0.418
MED29	0.417
MYH2	0.416
CDH24	0.416
PSMD3	0.416
TP53TG3B	0.415
CBWD6	0.415
RPS2	0.414
RPS28	0.414
PPAN	0.414
TP53TG3C	0.414
TP53TG3	0.414
NBPF10	0.413
PSMB1	0.413
SLC38A7	0.413
SULT2B1	0.412
ZNF106	0.412
XAB2	0.411
LOC643669	0.411
SNRPA1	0.411
IK	0.41
HAUS4	0.41
S1PR4	0.409
DDX47	0.409
RPL6	0.408
GOLGA6L6	0.408
GBF1	0.408
KIF11	0.407
PSMD1	0.407
PSAP	0.406
PSMB2	0.405
DOCK6	0.404
YTHDC1	0.404
AATF	0.404
TWISTNB	0.404
TOP1MT	0.403
PPFIA4	0.403
TSG101	0.403
SULT1A4	0.402
CWC15	0.402
SULT1A3	0.402
MCOLN1	0.402
KIF3C	0.402
ACSF2	0.402
MED15	0.402
NARFL	0.401
NBPF16	0.401
CNPY3	0.401
CLN6	0.401
CNOT1	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2419
Expression level (log2 read counts): -4.27

Expression Distribution

Screen	Score
BVD-523 15μM R02 exp67	-1.79
iCRT14 30μM R08 exp492	-1.71
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.86

calcium-dependent activation of synaptic vesicle fusion
positive regulation of synaptic vesicle fusion to presynaptic active zone membrane
regulation of synaptic vesicle fusion to presynaptic active zone membrane
positive regulation of synaptic vesicle exocytosis
positive regulation of vesicle fusion
presynaptic modulation of chemical synaptic transmission
dense core granule
positive regulation of calcium ion-dependent exocytosis
positive regulation of neurotransmitter secretion
exocytic vesicle
regulation of vesicle fusion
hippocampal mossy fiber to CA3 synapse
integral component of synaptic vesicle membrane
positive regulation of neurotransmitter transport
clathrin binding
regulation of dopamine secretion
calcium-ion regulated exocytosis
regulation of calcium ion-dependent exocytosis
positive regulation of regulated secretory pathway
clathrin-coated vesicle membrane
syntaxin binding
calcium-dependent phospholipid binding
phosphatidylserine binding
regulation of catecholamine secretion
synaptic vesicle exocytosis
SNARE binding
phosphatidylinositol-4,5-bisphosphate binding
regulation of synaptic vesicle exocytosis
cellular response to calcium ion
positive regulation of exocytosis
regulation of amine transport
secretory granule membrane
regulation of response to drug
signal release from synapse
neurotransmitter secretion
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
synaptic vesicle cycle
vesicle-mediated transport in synapse
regulation of neurotransmitter transport