SNRNP70
Gene Information
- Official Symbol: SNRNP70
- Official Name: small nuclear ribonucleoprotein U1 subunit 70
- Aliases and Previous Symbols: N/A
- Entrez ID: 6625
- UniProt: P08621
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| U1snRNP70 N |
| RRM 1 |
GO Terms
| negative regulation of chaperone-mediated autophagy |
| negative regulation of protein refolding |
| regulation of protein refolding |
| negative regulation of protein folding |
| U1 snRNA binding |
| regulation of chaperone-mediated autophagy |
| regulation of protein folding |
| U1 snRNP |
| positive regulation of mRNA splicing, via spliceosome |
| positive regulation of mRNA processing |
| positive regulation of RNA splicing |
| positive regulation of mRNA metabolic process |
| regulation of ATPase activity |
| negative regulation of autophagy |
| spliceosomal complex |
| regulation of mRNA splicing, via spliceosome |
| negative regulation of protein catabolic process |
| regulation of RNA splicing |
| regulation of mRNA processing |
| mRNA binding |
| negative regulation of cellular catabolic process |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| RNA splicing, via transesterification reactions |
| negative regulation of catabolic process |
| regulation of mRNA metabolic process |
| regulation of autophagy |
| regulation of protein catabolic process |
| RNA splicing |
| nuclear speck |
| mRNA processing |
| mRNA metabolic process |
| regulation of cellular catabolic process |
| RNA processing |
| regulation of catabolic process |
| negative regulation of protein metabolic process |
| regulation of hydrolase activity |
| RNA binding |
| RNA metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of gene expression |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TFIP11 | 0.52 |
| PSMB4 | 0.506 |
| RBM39 | 0.492 |
| CLN6 | 0.489 |
| PSAP | 0.488 |
| PAF1 | 0.478 |
| OSBP | 0.471 |
| ATP6V1C1 | 0.47 |
| ORC6 | 0.469 |
| PSMB3 | 0.462 |
| AKIRIN2 | 0.459 |
| RPL7L1 | 0.459 |
| SF3A3 | 0.457 |
| VASN | 0.456 |
| NARFL | 0.456 |
| CDC73 | 0.455 |
| SUPT5H | 0.455 |
| ORC1 | 0.451 |
| SF3A2 | 0.446 |
| CHD4 | 0.446 |
| CACTIN | 0.439 |
| MFSD12 | 0.436 |
| SYT9 | 0.434 |
| CKAP5 | 0.434 |
| TCEB3CL2 | 0.433 |
| RPS19BP1 | 0.432 |
| IGFN1 | 0.432 |
| TBC1D3G | 0.432 |
| INTS6 | 0.431 |
| POLA2 | 0.429 |
| IK | 0.427 |
| RPL14 | 0.427 |
| SLC4A1 | 0.424 |
| TCEB3C | 0.422 |
| TBC1D3C | 0.42 |
| EIF4A3 | 0.42 |
| SF3A1 | 0.419 |
| C1QTNF9B | 0.419 |
| PSMA6 | 0.418 |
| TBC1D3H | 0.418 |
| TICRR | 0.417 |
| WDR87 | 0.417 |
| CDC6 | 0.416 |
| KCTD17 | 0.414 |
| TAF15 | 0.414 |
| EXD1 | 0.414 |
| SSH2 | 0.411 |
| SEC13 | 0.411 |
| NUFIP2 | 0.411 |
| PSMD3 | 0.41 |
| CDH24 | 0.409 |
| EXOSC6 | 0.408 |
| ISCU | 0.408 |
| RPL35 | 0.407 |
| RPL6 | 0.406 |
| ARCN1 | 0.406 |
| RBBP5 | 0.405 |
| TCEB3CL | 0.404 |
| CACNA1A | 0.404 |
| MT1E | 0.404 |
| C14orf93 | 0.403 |
| ATP6V0C | 0.401 |
| TOP1MT | 0.401 |
| RRN3 | 0.401 |
| RPS2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 679/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 25/28 |
| blood | 27/28 |
| bone | 26/26 |
| breast | 32/33 |
| central nervous system | 52/56 |
| cervix | 2/4 |
| colorectal | 16/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 13/16 |
| kidney | 15/21 |
| liver | 19/20 |
| lung | 66/75 |
| lymphocyte | 16/16 |
| ovary | 24/26 |
| pancreas | 23/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 21/24 |
| soft tissue | 9/9 |
| thyroid | 1/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 27/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 587
- Expression level (log2 read counts): 8.39
Expression Distribution
SNRNP70 Expression in NALM6 Cells: 8.39
