TAF15
Gene Information
- Official Symbol: TAF15
- Official Name: TATA-box binding protein associated factor 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 8148
- UniProt: Q92804
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
- UniProt Summary: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2028
- Expression level (log2 read counts): 8.17
TAF15 Expression in NALM6 Cells: 8.17
