CACTIN
Gene Information
- Official Symbol: CACTIN
- Official Name: cactin, spliceosome C complex subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 58509
- UniProt: Q8WUQ7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. {ECO:0000269|PubMed:20829348}.
Pfam Domains GO Terms
Pfam Domains
| CactinC cactus |
| Cactin mid |
GO Terms
| negative regulation of lipopolysaccharide-mediated signaling pathway |
| negative regulation of type I interferon-mediated signaling pathway |
| negative regulation of interferon-beta production |
| negative regulation of interleukin-8 production |
| regulation of lipopolysaccharide-mediated signaling pathway |
| regulation of type I interferon-mediated signaling pathway |
| negative regulation of toll-like receptor signaling pathway |
| negative regulation of type I interferon production |
| regulation of interferon-beta production |
| negative regulation of innate immune response |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of cytokine-mediated signaling pathway |
| negative regulation of response to cytokine stimulus |
| regulation of toll-like receptor signaling pathway |
| regulation of interleukin-8 production |
| negative regulation of NF-kappaB transcription factor activity |
| catalytic step 2 spliceosome |
| negative regulation of response to biotic stimulus |
| regulation of type I interferon production |
| negative regulation of immune response |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of DNA-binding transcription factor activity |
| regulation of cytokine-mediated signaling pathway |
| cellular response to interleukin-1 |
| regulation of response to cytokine stimulus |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| response to interleukin-1 |
| negative regulation of defense response |
| cellular response to biotic stimulus |
| negative regulation of multi-organism process |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| negative regulation of cytokine production |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| negative regulation of response to external stimulus |
| RNA splicing |
| nuclear speck |
| negative regulation of protein phosphorylation |
| regulation of DNA-binding transcription factor activity |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of innate immune response |
| mRNA processing |
| cellular response to lipid |
| regulation of response to biotic stimulus |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| response to bacterium |
| mRNA metabolic process |
| regulation of cytokine production |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| response to lipid |
| RNA processing |
| defense response to other organism |
| cellular response to cytokine stimulus |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| RNA binding |
| regulation of protein phosphorylation |
| regulation of response to stress |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| immune response |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Etoposide 1μM R00 exp19 | -1.87 |
| GSK-J4 1.5μM R08 exp441 | -1.79 |
| ABT-702 5μM R06 exp261 | 1.82 |
| Apcin 50 to 100μM on day4 R04 exp176 | 1.9 |
| Disulfiram 4.3μM R06 exp281 | 1.98 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RPL35 | 0.572 |
| TCEB3C | 0.572 |
| PSMB4 | 0.557 |
| TCEB3CL | 0.548 |
| TCEB3CL2 | 0.547 |
| NARFL | 0.543 |
| TBC1D3H | 0.531 |
| CHD4 | 0.526 |
| ATP6V1C1 | 0.523 |
| RPS2 | 0.518 |
| TBC1D3G | 0.514 |
| PSMA6 | 0.514 |
| AQR | 0.514 |
| SUPT5H | 0.502 |
| TBC1D3F | 0.502 |
| NUPL1 | 0.501 |
| ITGA2B | 0.5 |
| DDTL | 0.498 |
| COL2A1 | 0.493 |
| GOLGA6L6 | 0.492 |
| TFIP11 | 0.491 |
| KCTD17 | 0.49 |
| CDC6 | 0.489 |
| TP53TG3C | 0.487 |
| TBC1D3I | 0.487 |
| TBC1D3E | 0.487 |
| TP53TG3 | 0.487 |
| TP53TG3B | 0.487 |
| TBC1D3K | 0.487 |
| TBC1D3C | 0.486 |
| TBC1D3L | 0.486 |
| ACSF2 | 0.483 |
| PSMB2 | 0.483 |
| RRP15 | 0.479 |
| ORC1 | 0.477 |
| NAPA | 0.477 |
| TSPY2 | 0.475 |
| NUP43 | 0.475 |
| COPG1 | 0.473 |
| SLC4A1 | 0.472 |
| DNTTIP2 | 0.472 |
| COPB1 | 0.471 |
| RAD51 | 0.471 |
| C1QTNF9B | 0.471 |
| ZNF830 | 0.47 |
| MT1E | 0.47 |
| RPS12 | 0.47 |
| CEBPZ | 0.47 |
| ISCU | 0.47 |
| PPIE | 0.469 |
| RNF113A | 0.469 |
| PSMB1 | 0.468 |
| TP53TG3D | 0.467 |
| NUF2 | 0.465 |
| PSMC1 | 0.465 |
| TBC1D3 | 0.464 |
| CHAF1A | 0.462 |
| LRR1 | 0.461 |
| ANKLE2 | 0.46 |
| CBWD3 | 0.46 |
| PSMC2 | 0.459 |
| ANKLE1 | 0.459 |
| SH3BP1 | 0.458 |
| ZFAND5 | 0.457 |
| TYMS | 0.457 |
| OSBP | 0.457 |
| FAM25B | 0.457 |
| RPL6 | 0.456 |
| PWP2 | 0.454 |
| TSPY1 | 0.453 |
| UTP3 | 0.453 |
| DHX38 | 0.453 |
| NBPF10 | 0.452 |
| MED14 | 0.451 |
| RPL38 | 0.451 |
| FAM160A1 | 0.451 |
| ATP6V1A | 0.449 |
| HAP1 | 0.448 |
| SYT9 | 0.448 |
| RANBP2 | 0.448 |
| MYB | 0.448 |
| RPS19BP1 | 0.448 |
| EXOSC8 | 0.448 |
| GOLGA8O | 0.447 |
| RPL34 | 0.447 |
| AATF | 0.447 |
| KRT78 | 0.446 |
| CDC73 | 0.446 |
| CBWD6 | 0.446 |
| EXOSC6 | 0.446 |
| NSF | 0.446 |
| FBXW9 | 0.445 |
| LAD1 | 0.445 |
| DDT | 0.444 |
| EXOSC3 | 0.444 |
| RIOK2 | 0.443 |
| CBWD5 | 0.443 |
| NUP160 | 0.442 |
| CLN6 | 0.442 |
| SF3A1 | 0.441 |
| S1PR4 | 0.441 |
| TSG101 | 0.441 |
| IK | 0.44 |
| TICRR | 0.44 |
| CCDC116 | 0.44 |
| HINFP | 0.44 |
| POLR2J3 | 0.439 |
| AKIRIN2 | 0.439 |
| SNRNP70 | 0.439 |
| POLR2A | 0.438 |
| RBBP5 | 0.437 |
| RBM39 | 0.437 |
| CDC45 | 0.436 |
| RRP7A | 0.434 |
| PSMD14 | 0.434 |
| ATP6AP1 | 0.433 |
| ATP6V1B2 | 0.432 |
| TSPY8 | 0.431 |
| MYO1H | 0.431 |
| EXOSC9 | 0.431 |
| MBTD1 | 0.431 |
| OR10G3 | 0.43 |
| ACD | 0.43 |
| KRT5 | 0.43 |
| NPIPB5 | 0.43 |
| PSMD3 | 0.43 |
| PSMA7 | 0.43 |
| HIVEP3 | 0.43 |
| NOL12 | 0.429 |
| SNRPA1 | 0.429 |
| VPS28 | 0.429 |
| NUP85 | 0.428 |
| ORC6 | 0.428 |
| PSMC6 | 0.427 |
| DDX41 | 0.427 |
| GID4 | 0.427 |
| MADCAM1 | 0.425 |
| POLR1A | 0.424 |
| TIMELESS | 0.424 |
| AAMP | 0.424 |
| RRM1 | 0.423 |
| VASN | 0.423 |
| GPRIN2 | 0.423 |
| EXOSC5 | 0.422 |
| RPL30 | 0.422 |
| SMTN | 0.421 |
| BRD2 | 0.42 |
| POLE | 0.42 |
| NOL8 | 0.419 |
| DTL | 0.419 |
| WDR87 | 0.418 |
| TERF1 | 0.418 |
| PSMD2 | 0.417 |
| SF3A2 | 0.417 |
| CHMP2A | 0.417 |
| MKI67IP | 0.416 |
| RPL17 | 0.416 |
| COPA | 0.416 |
| POLR2F | 0.416 |
| BYSL | 0.415 |
| IGFN1 | 0.415 |
| DIDO1 | 0.414 |
| CHCHD3 | 0.414 |
| DOCK6 | 0.414 |
| PLK1 | 0.414 |
| PCF11 | 0.414 |
| CEP192 | 0.413 |
| LOC643669 | 0.413 |
| CHMP4B | 0.413 |
| CDH24 | 0.413 |
| ZNF655 | 0.412 |
| NPIPA5 | 0.412 |
| SLC6A17 | 0.412 |
| EXD1 | 0.411 |
| MEPCE | 0.411 |
| POLR2L | 0.411 |
| HNRNPC | 0.41 |
| GOLGA6L1 | 0.41 |
| POLA2 | 0.408 |
| PRPF19 | 0.407 |
| CCDC64B | 0.407 |
| ZNF148 | 0.406 |
| NOL9 | 0.406 |
| ARCN1 | 0.405 |
| EGR2 | 0.405 |
| RPS5 | 0.404 |
| SKIV2L2 | 0.404 |
| XAB2 | 0.404 |
| SULT2B1 | 0.404 |
| SAP30BP | 0.403 |
| NOP14 | 0.403 |
| CGB2 | 0.403 |
| RRN3 | 0.402 |
| SF3A3 | 0.402 |
| SEC13 | 0.402 |
| FCN2 | 0.402 |
| RPL37A | 0.401 |
| NCL | 0.401 |
| SLC38A7 | 0.401 |
| NFS1 | 0.401 |
| RRP1 | 0.4 |
| XYLT2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 566/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 23/28 |
| blood | 21/28 |
| bone | 18/26 |
| breast | 28/33 |
| central nervous system | 36/56 |
| cervix | 4/4 |
| colorectal | 14/17 |
| esophagus | 5/13 |
| fibroblast | 1/1 |
| gastric | 12/16 |
| kidney | 14/21 |
| liver | 16/20 |
| lung | 58/75 |
| lymphocyte | 14/16 |
| ovary | 20/26 |
| pancreas | 21/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 8/15 |
| prostate | 1/1 |
| skin | 18/24 |
| soft tissue | 7/9 |
| thyroid | 1/2 |
| upper aerodigestive | 15/22 |
| urinary tract | 19/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1929
- Expression level (log2 read counts): 5.89
Expression Distribution
CACTIN Expression in NALM6 Cells: 5.89
