PWP2

Gene Information

Official Symbol: PWP2
Official Name: PWP2 small subunit processome component
Aliases and Previous Symbols: N/A
Entrez ID: 5822
UniProt: Q15269
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-1.9
Doxorubicin 0.02μM R08 exp478	-1.81
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.79
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.79
ABT-702 5μM R06 exp261	2.41

Gene	Correlation
LRR1	0.55
TCEB3C	0.538
TCEB3CL2	0.524
PSMD3	0.513
C14orf93	0.513
TBC1D3E	0.502
TCEB3CL	0.502
RBBP5	0.502
TBC1D3I	0.502
TBC1D3K	0.501
TBC1D3L	0.501
NPIPB8	0.494
PSMC2	0.491
PSMB2	0.49
RPL35	0.486
TBC1D3C	0.483
TBC1D3G	0.483
PSMD14	0.483
COPE	0.483
HIST2H3A	0.483
HIST2H3C	0.482
NUP160	0.48
BYSL	0.48
SF3A1	0.479
RAD51	0.479
RPS2	0.477
VASN	0.476
CHD4	0.476
POLE	0.47
SLC4A1	0.469
CBWD3	0.469
GOLGA8O	0.468
UPF1	0.468
COL2A1	0.466
TBC1D3H	0.464
CDC45	0.464
PSMD1	0.464
MYO1H	0.463
HIST2H2BF	0.462
PSMD11	0.462
GOLGA6L4	0.462
PSMC4	0.462
DDTL	0.456
SLC38A7	0.456
CBWD6	0.456
MT1E	0.456
C1QTNF9B	0.455
CACTIN	0.454
C3	0.453
POLA1	0.452
ACSF2	0.451
LAD1	0.451
POLR2J3	0.451
RPS7	0.45
SLC6A17	0.449
TBC1D3	0.448
CDC73	0.447
TBC1D3F	0.447
CBWD5	0.447
SART1	0.447
ZNF830	0.445
SUPT5H	0.445
RPS5	0.443
CCDC64B	0.443
KIF3C	0.443
PSMC1	0.441
PSMA6	0.441
GOLGA6L3	0.44
NOL10	0.439
PSMD2	0.437
CDCA3	0.437
PAF1	0.437
ZNF106	0.436
ZFAND5	0.434
PSMB4	0.434
OGFR	0.433
RRP7A	0.433
COPG1	0.432
ATP6V1C1	0.431
PBXIP1	0.43
FAM160A1	0.43
FTSJ3	0.43
PAN3	0.429
TICRR	0.427
COPB1	0.426
SEZ6L2	0.426
URB2	0.426
FAM86B2	0.425
ZNF655	0.425
DDT	0.424
MYB	0.424
RPL38	0.424
PRIM1	0.422
PSMD6	0.421
UQCRH	0.421
PDE4DIP	0.421
NUPL1	0.42
CCDC116	0.42
SNRPA1	0.42
COPB2	0.419
RPSA	0.419
POLA2	0.419
CDC6	0.418
PRMT8	0.418
KCTD17	0.418
NOP14	0.417
DNTTIP2	0.416
TP53TG3B	0.416
TP53TG3	0.416
HAP1	0.416
TP53TG3D	0.416
POLR2F	0.415
AQR	0.415
ATP13A1	0.415
PAN2	0.414
TP53TG3C	0.414
CCNA2	0.414
TWISTNB	0.414
AKIRIN2	0.413
SEC13	0.413
SULT1A3	0.412
ITGA2B	0.412
RIOK2	0.411
SULT1A4	0.411
MYT1L	0.41
TIMELESS	0.41
NBPF10	0.41
PSMC6	0.41
RPL6	0.408
TFIP11	0.407
RPS28	0.406
WDR87	0.406
RPS11	0.406
RPS20	0.404
KPNB1	0.404
COPA	0.404
NARFL	0.404
HEATR1	0.403
ALDH1B1	0.403
AHCTF1	0.402
RPS12	0.402
IGFN1	0.402
ANKLE2	0.401
EXOSC9	0.401
MPHOSPH10	0.401
ATP6AP2	0.401
NOL7	0.4
NPIPB9	0.4

Global Fraction of Cell Lines Where Essential: 674/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	27/28
bone	26/26
breast	27/33
central nervous system	56/56
cervix	4/4
colorectal	15/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	20/21
liver	19/20
lung	65/75
lymphocyte	15/16
ovary	25/26
pancreas	19/24
peripheral nervous system	15/16
plasma cell	11/15
prostate	0/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	26/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1062
Expression level (log2 read counts): 5.81

Expression Distribution

Utp12
WD40

Pwp2p-containing subcomplex of 90S preribosome
ribosomal small subunit assembly
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
small-subunit processome
maturation of SSU-rRNA
ribosome assembly
ribosomal small subunit biogenesis
rRNA processing
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
organelle assembly
cellular protein-containing complex assembly
RNA processing
RNA binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression