ALDH1B1

Entrez Summary: This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008].
UniProt Summary: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
ethanol oxidation
ethanol catabolic process
aldehyde dehydrogenase (NAD) activity
primary alcohol catabolic process
ethanol metabolic process
NAD binding
antibiotic catabolic process
alcohol catabolic process
organic hydroxy compound catabolic process
primary alcohol metabolic process
antibiotic metabolic process
drug catabolic process
alcohol metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
small molecule catabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
drug metabolic process
intracellular membrane-bounded organelle
oxidation-reduction process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process