MYO18A

Gene Information

Official Symbol: MYO18A
Official Name: myosin XVIIIA
Aliases and Previous Symbols: N/A
Entrez ID: 399687
UniProt: Q92614
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016].
UniProt Summary: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
PDE4DIP	0.482
PSMB2	0.479
C1QTNF9B	0.476
CHD4	0.471
C14orf93	0.466
AKIRIN2	0.466
TCEB3CL2	0.46
COPG1	0.449
CCDC94	0.447
SSH2	0.443
TBC1D3G	0.442
CCNA2	0.442
TBC1D3I	0.441
TBC1D3E	0.441
TBC1D3K	0.44
TBC1D3L	0.44
CGB2	0.439
GOLGA6L4	0.439
TBC1D3C	0.438
SLC4A1	0.438
PSMD3	0.437
TBC1D3	0.435
CCDC64B	0.434
EXOSC9	0.432
S1PR4	0.431
NUPL1	0.431
TBC1D3H	0.43
NAPA	0.429
RRN3	0.427
PSMB4	0.427
POLA1	0.425
ALDH1B1	0.424
EXOSC5	0.423
KCTD17	0.423
TRIM52	0.421
RBBP5	0.421
TFIP11	0.419
POLR2J3	0.418
RPL35	0.417
HMGCR	0.417
COPE	0.416
CDH24	0.416
TCEB3C	0.416
ORC1	0.415
COPA	0.414
CHST3	0.414
PAF1	0.413
TBC1D3F	0.413
ARCN1	0.411
SUPT5H	0.411
MT1E	0.41
RPL6	0.41
ZNF106	0.408
TCEB3CL	0.408
CHMP2A	0.406
RPS7	0.404
PSMD11	0.403
POLE	0.402
VASN	0.401
PBXIP1	0.401
LRR1	0.4
POLR1A	0.4
EXOSC4	0.4

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2201
Expression level (log2 read counts): 8.51

Expression Distribution

Screen	Score
IU1-47 25μM R04 exp182	1.78
L-BMAA 500 to 750μM on day4 R04 exp185	1.8
NFN1 0.1μM R01 exp49	2.01

Myosin head
Myosin tail 1
PDZ

positive regulation of opsonization
asymmetric Golgi ribbon formation
regulation of opsonization
Golgi ribbon formation
actomyosin
establishment of epithelial cell polarity
myosin complex
ADP binding
regulation of macrophage activation
positive regulation of phagocytosis
endoplasmic reticulum-Golgi intermediate compartment
Golgi vesicle budding
regulation of phagocytosis
vesicle budding from membrane
actomyosin structure organization
establishment of cell polarity
Golgi organization
trans-Golgi network
establishment or maintenance of cell polarity
actin filament binding
positive regulation of immune effector process
ATPase activity
positive regulation of protein secretion
positive regulation of peptide secretion
vesicle organization
Golgi vesicle transport
positive regulation of secretion by cell
endomembrane system organization
positive regulation of protein transport
positive regulation of secretion
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of immune effector process
actin cytoskeleton organization
regulation of peptide secretion
regulation of vesicle-mediated transport
actin filament-based process
regulation of leukocyte activation
cell surface
Golgi membrane