NUPL1

Gene Information

Official Symbol: NUP58
Official Name: nucleoporin 58
Aliases and Previous Symbols: N/A
Entrez ID: 9818
UniProt: Q9BVL2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70581}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.08
Brefeldin A 0.02μM R00 exp8	-1.98
Mitomycin-C 0.06μM R08 exp503	-1.74
Vinblastine 0.002μM R01 exp60	1.76
Citral 50μM R06 exp274	1.86
PF-06409577 20μM R07 exp389	1.91
BH1 1μM R04 exp169	1.92
RO-3306 3 to 4μM on day4 R04 exp165	1.94
DABN 2μM R00 exp16	1.96
Alpha-Amanitin 0.5μM R00 exp5	2.02

Gene	Correlation
PSMB4	0.593
TCEB3CL2	0.574
HAP1	0.555
CHD4	0.552
TCEB3C	0.547
TBC1D3G	0.547
TBC1D3H	0.547
MT1E	0.544
DTL	0.542
C1QTNF9B	0.539
PSMD3	0.539
ISCU	0.537
CBWD3	0.536
RPS2	0.536
TCEB3CL	0.535
PSMD1	0.534
TBC1D3F	0.534
CCNA2	0.531
VASN	0.531
SSH2	0.528
LRR1	0.527
TICRR	0.525
CDCA3	0.524
TFIP11	0.52
PSMA6	0.519
DDTL	0.519
DOCK6	0.518
POLE	0.518
AAMP	0.518
ANKLE2	0.516
COPB1	0.514
CBWD5	0.513
CCDC64B	0.513
FBXW9	0.512
SYT9	0.512
EXOSC5	0.51
POLR2J3	0.51
TWISTNB	0.509
RPS12	0.509
NUP160	0.509
ORC1	0.506
TBC1D3	0.505
PSMB2	0.505
HIST1H2BE	0.504
PPFIA4	0.503
AKIRIN2	0.502
ZFAND5	0.502
CACTIN	0.501
TSPY8	0.498
KCTD17	0.498
SUPT6H	0.498
CBWD6	0.497
TBC1D3C	0.497
SNIP1	0.494
S1PR4	0.494
SART1	0.494
NPIPB5	0.493
RAD21	0.492
ZNF655	0.492
PSMC6	0.489
ZNF830	0.489
SEC13	0.489
COPG1	0.488
C14orf93	0.487
TYMS	0.487
CDC45	0.486
NOL8	0.485
XYLT2	0.484
GOSR2	0.484
MED14	0.483
RPS28	0.483
ATP6V1C1	0.482
POLR2F	0.481
NBPF16	0.481
DNTTIP2	0.481
SUPT5H	0.48
ORC6	0.48
CDC6	0.479
TP53TG3B	0.479
TP53TG3	0.478
TP53TG3C	0.477
EGR2	0.477
GOLGA8O	0.476
HIVEP3	0.476
OR10G3	0.475
NUP155	0.475
PCF11	0.475
IGFN1	0.474
SNRPA1	0.474
WDR87	0.473
KRT78	0.473
COPA	0.472
PSMC1	0.472
MED17	0.471
PSMC2	0.471
ACSF2	0.471
RPSA	0.47
STIL	0.47
CDC73	0.467
NBPF10	0.466
COPE	0.466
RPS9	0.465
NUP205	0.465
NOL10	0.465
TBC1D3E	0.464
TBC1D3I	0.464
ACD	0.464
TSG101	0.463
PSMD11	0.463
PSMA7	0.463
TBC1D3L	0.463
MADCAM1	0.463
TBC1D3K	0.463
TIMELESS	0.463
NOP16	0.462
RPS19BP1	0.462
SCAF1	0.462
SLC4A1	0.461
GOLGA6L6	0.46
DYNC1I2	0.46
DIDO1	0.46
SLC38A7	0.46
RRP15	0.46
CHAF1A	0.459
ARCN1	0.459
CCDC116	0.458
NUP43	0.456
PIGS	0.454
USP36	0.453
PSMA1	0.453
NUP54	0.452
NSF	0.451
GAR1	0.451
HMGCR	0.451
PAN3	0.45
NFATC4	0.45
RPL35	0.449
IK	0.449
KPNB1	0.449
GOLGA6A	0.448
FAM25B	0.447
UPF1	0.446
CEBPZ	0.446
POLA1	0.446
NARFL	0.446
TRAIP	0.445
RPL34	0.444
PSMB3	0.444
ATP6V1A	0.443
RPL6	0.443
FAM160A1	0.443
CEP192	0.443
PSMB1	0.442
RANGAP1	0.442
AQR	0.441
PAF1	0.441
RAD51	0.441
ATP6AP1	0.44
FAM231C	0.44
FAM231A	0.439
MSH5	0.439
AHCTF1	0.438
BYSL	0.437
EIF4A3	0.437
CKAP5	0.436
SLC6A17	0.436
XPO1	0.435
NUP153	0.435
ZNF106	0.434
RBBP5	0.434
LOC643669	0.434
HINFP	0.434
RPL14	0.434
CHMP2A	0.432
DDT	0.432
RILPL2	0.432
COPB2	0.432
POLA2	0.431
MYO18A	0.431
EXOSC3	0.43
XAB2	0.428
RPS5	0.427
SMTN	0.427
POLR1A	0.427
RRN3	0.427
MDM2	0.426
CCDC94	0.426
AAAS	0.426
RPL26	0.426
SLC23A3	0.426
GOLGA8J	0.426
GON4L	0.425
GOLGA6L4	0.425
SULT2B1	0.425
PLK1	0.424
VPS28	0.424
GOLGA6L3	0.424
RBM39	0.423
RANBP2	0.422
PSMC4	0.422
GOLGA8K	0.422
RFPL3	0.421
TP53TG3D	0.421
CSNK1A1	0.42
ATP6AP2	0.42
PSMD2	0.42
PWP2	0.42
TUBA8	0.42
CDCA5	0.42
COPZ1	0.419
ALDH1B1	0.419
PSMD7	0.417
SAP30BP	0.416
PAN2	0.416
SMG7	0.416
NAPA	0.415
RNF4	0.415
SEMA6B	0.414
FCN2	0.414
PARP3	0.414
MYO1H	0.414
SNRNP200	0.413
RPS11	0.413
NUP107	0.413
NDC80	0.413
HIST2H3A	0.412
RPL7L1	0.412
HIST2H3C	0.412
BID	0.412
CWC22	0.411
NUP85	0.411
SF3A1	0.411
ZNF541	0.411
UQCRH	0.411
MCOLN1	0.41
CDT1	0.41
RFXANK	0.41
ANKLE1	0.409
RIOK2	0.408
NUP133	0.408
PDE4DIP	0.408
KIF3C	0.408
DDX47	0.407
PSMD6	0.407
SNAPC3	0.406
POLR2L	0.406
POLE2	0.405
ITGA2B	0.405
UTP3	0.405
NOL12	0.404
DDX56	0.404
PSMC5	0.403
SH3BP1	0.403
CDK12	0.403
RPS7	0.402
HNRNPC	0.402
PRIM1	0.402
CLN6	0.401
GBF1	0.401
AATF	0.401
RPLP1	0.4
NDC1	0.4
EXD1	0.4
RNPC3	0.4

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1171
Expression level (log2 read counts): 7.23

Expression Distribution

protein heterotrimerization
nuclear localization sequence binding
structural constituent of nuclear pore
protein heterotetramerization
tRNA export from nucleus
tRNA-containing ribonucleoprotein complex export from nucleus
tRNA transport
ncRNA export from nucleus
intracellular transport of virus
protein trimerization
host cell
regulation of protein import into nucleus
transport of virus
regulation of protein import
protein sumoylation
multi-organism localization
multi-organism transport
nuclear pore
regulation of glycolytic process
regulation of cellular response to heat
regulation of gene silencing by miRNA
regulation of carbohydrate catabolic process
regulation of gene silencing by RNA
regulation of posttranscriptional gene silencing
regulation of nucleocytoplasmic transport
protein heterooligomerization
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
viral transcription
regulation of purine nucleotide metabolic process
regulation of protein localization to nucleus
regulation of nucleotide metabolic process
regulation of ATP metabolic process
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
regulation of gene silencing
viral gene expression
protein export from nucleus
protein tetramerization