DYNC1I2
Gene Information
- Official Symbol: DYNC1I2
- Official Name: dynein cytoplasmic 1 intermediate chain 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1781
- UniProt: Q13409
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Dynein IC2 |
| WD40 |
GO Terms
| dynein heavy chain binding |
| cytoplasmic dynein complex |
| dynein light chain binding |
| ATP-dependent microtubule motor activity, plus-end-directed |
| microtubule motor activity |
| ciliary basal body-plasma membrane docking |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| vesicle |
| organelle localization by membrane tethering |
| antigen processing and presentation of exogenous peptide antigen |
| membrane docking |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| antigen processing and presentation |
| mitotic cell cycle phase transition |
| microtubule-based movement |
| cell cycle phase transition |
| microtubule |
| cilium assembly |
| cilium organization |
| Golgi vesicle transport |
| regulation of mitotic cell cycle phase transition |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| cell projection assembly |
| centrosome |
| organelle localization |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| microtubule-based process |
| mitotic cell cycle |
| viral process |
| regulation of cell cycle process |
| organelle assembly |
| symbiotic process |
| interspecies interaction between organisms |
| cell cycle process |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| regulation of cell cycle |
| cell cycle |
| intracellular transport |
| movement of cell or subcellular component |
| establishment of localization in cell |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vemurafenib 6.6μM R08 exp434 | -1.76 |
| BH1 1μM R04 exp169 | 1.7 |
| Vinorelbine 0.001μM R05 exp249 | 1.7 |
| A-395 10μM R05 exp218 | 1.85 |
| PFI-2 4μM R05 exp239 | 1.89 |
| SB743921 0.001μM R05 exp244 | 2.06 |
| Colchicine 0.009μM R05 exp215 | 2.13 |
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 704/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 25/28 |
| bone | 25/26 |
| breast | 32/33 |
| central nervous system | 54/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 18/21 |
| liver | 20/20 |
| lung | 70/75 |
| lymphocyte | 15/16 |
| ovary | 23/26 |
| pancreas | 24/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 22/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 27/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 1338
- Expression level (log2 read counts): 6.26
Expression Distribution
DYNC1I2 Expression in NALM6 Cells: 6.26
