GON4L

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Atovaquone 15μM R08 exp451	-1.93
Aphidicolin 0.4μM R08 exp440	-1.86
Hinokiflavone 12μM R08 exp487	-1.78
Nicotinamide 2000μM R01 exp50	1.73
Rapamycin 10μM R00 exp30	1.73
SB202190 10μM R03 exp148	1.74
JQ1 0.01μM R03 exp130	1.77
NFN1 1μM R03 exp100	1.81
Ethambutol 25μM R08 exp481	1.82
All-trans-Retinoic-Acid 40μM R07 exp334	1.84
Taxol 0.002μM R01 exp54	1.91
Bortezomib 0.005μM R00 exp6	1.92
Prochlorperazine 5.2μM R02 exp77	1.92
Doxycycline 10μM R00 exp18	1.95
KU-0063794 3.8μM R02 exp71	1.97
2-Methoxyestradiol 0.2μM R01 exp40	2.12
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.27

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

B cell differentiation
B cell activation
lymphocyte differentiation
transcription corepressor activity
nuclear body
leukocyte differentiation
lymphocyte activation
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
leukocyte activation
cell activation
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression