SIX5

Gene Information

Official Symbol: SIX5
Official Name: SIX homeobox 5
Aliases and Previous Symbols: N/A
Entrez ID: 147912
UniProt: Q8N196
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009].
UniProt Summary: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'- TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2816
Expression level (log2 read counts): 0.87

Expression Distribution

Homeobox KN
Homeobox

negative regulation of skeletal muscle cell proliferation
negative regulation of skeletal muscle satellite cell proliferation
regulation of skeletal muscle satellite cell proliferation
regulation of skeletal muscle cell proliferation
transcription regulatory region sequence-specific DNA binding
lens development in camera-type eye
spermatid development
spermatid differentiation
transcription factor complex
germ cell development
camera-type eye development
cellular process involved in reproduction in multicellular organism
eye development
visual system development
sensory system development
RNA polymerase II proximal promoter sequence-specific DNA binding
spermatogenesis
sensory organ development
male gamete generation
developmental process involved in reproduction
negative regulation of cell population proliferation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific