GON4L [The Human Chemical-Genetic Interaction Map Project]

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======= GON4L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GON4L
  * **<color #00a2e8>Official Name</color>**: gon-4 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54856|54856]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3T8J9|Q3T8J9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GON4L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GON4L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610393|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|B cell differentiation|
|B cell activation|
|lymphocyte differentiation|
|transcription corepressor activity|
|nuclear body|
|leukocyte differentiation|
|lymphocyte activation|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|leukocyte activation|
|cell activation|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.93|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.86|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.78|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.73|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.73|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.74|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.77|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.81|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.82|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.84|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.91|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.92|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.92|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.95|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.97|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.12|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rbm39|RBM39]]|0.474|
|[[:human genes:t:tfip11|TFIP11]]|0.466|
|[[:human genes:o:orc1|ORC1]]|0.463|
|[[:human genes:w:wdr87|WDR87]]|0.457|
|[[:human genes:o:orc6|ORC6]]|0.446|
|[[:human genes:t:ticrr|TICRR]]|0.445|
|[[:human genes:c:c14orf93|C14orf93]]|0.44|
|[[:human genes:c:cdc73|CDC73]]|0.437|
|[[:human genes:c:cdc6|CDC6]]|0.436|
|[[:human genes:t:tceb3c|TCEB3C]]|0.434|
|[[:human genes:s:s1pr4|S1PR4]]|0.431|
|[[:human genes:c:cdca3|CDCA3]]|0.431|
|[[:human genes:v:vasn|VASN]]|0.43|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.428|
|[[:human genes:h:hivep3|HIVEP3]]|0.426|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.426|
|[[:human genes:n:nupl1|NUPL1]]|0.425|
|[[:human genes:p:paf1|PAF1]]|0.419|
|[[:human genes:c:chmp2a|CHMP2A]]|0.412|
|[[:human genes:r:rpsa|RPSA]]|0.411|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.411|
|[[:human genes:c:chd4|CHD4]]|0.409|
|[[:human genes:z:znf106|ZNF106]]|0.409|
|[[:human genes:g:golga6a|GOLGA6A]]|0.408|
|[[:human genes:e:egr2|EGR2]]|0.408|
|[[:human genes:p:psmb4|PSMB4]]|0.408|
|[[:human genes:a:aatf|AATF]]|0.404|
|[[:human genes:l:lrr1|LRR1]]|0.402|
|[[:human genes:s:stil|STIL]]|0.402|
|[[:human genes:h:hap1|HAP1]]|0.401|
|[[:human genes:p:pold1|POLD1]]|0.401|
|[[:human genes:s:six5|SIX5]]|0.4|
|[[:human genes:b:bms1|BMS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2032
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GON4L Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>