POLE2

Entrez Summary: DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017].
UniProt Summary: Participates in DNA repair and in chromosomal DNA replication.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TIC10 10μM R08 exp532	-2.04
GSK-J4 1.5μM R08 exp441	-1.97
Cerivastatin 0.15μM R05 exp226	-1.71
FBS-Wisent 0.1 R07 exp426	1.73
CCT251545 0.2μM R06 exp271	1.77
BAY-598 4μM R05 exp220	1.84
UNC2400 2μM R03 exp156	1.84
Cyclosporin-A 3μM R07 exp348	1.9
Erlotinib 10μM R05 exp216	1.93
Mdivi-1 15μM R05 exp217	2.02
NN-Diethyl-meta-toluamide 100μM R05 exp237	2.14
YM155 0.001μM R08 exp432	2.15
Nicotinamide 1000μM R03 exp101	2.16
Dihydrosphingosine 8μM R08 exp476	2.17
Chlorpromazine 10μM R07 exp344	2.24
GSK-J4 1μM R07 exp362	2.25
Momordin-Ic 10μM R08 exp506	2.25
Bisphenol F 50μM R08 exp457	2.42
Dexamethasone 0.006μM R07 exp351	2.42
CCT251545 20μM R07 exp326	2.46
Rapamycin 2μM plus FK-506 5μM R07 exp308	2.54
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.59
UM0131023 0.05μM R05 exp248	2.78

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

DNA pol E B
Dpoe2NT

epsilon DNA polymerase complex
error-prone translesion synthesis
telomere maintenance via semi-conservative replication
DNA-directed DNA polymerase activity
DNA replication initiation
translesion synthesis
nuclear DNA replication
cell cycle DNA replication
DNA synthesis involved in DNA repair
postreplication repair
telomere maintenance
telomere organization
DNA biosynthetic process
G1/S transition of mitotic cell cycle
DNA-dependent DNA replication
cell cycle G1/S phase transition
DNA replication
mitotic cell cycle phase transition
cell cycle phase transition
nuclear body
anatomical structure homeostasis
DNA repair
mitotic cell cycle process
mitotic cell cycle
intracellular membrane-bounded organelle
DNA metabolic process
cellular response to DNA damage stimulus
cellular homeostasis
cell cycle process
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cell cycle
DNA binding
cellular nitrogen compound biosynthetic process
homeostatic process
cellular response to stress
cellular macromolecule biosynthetic process