POLE2 [The Human Chemical-Genetic Interaction Map Project]

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======= POLE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLE2
  * **<color #00a2e8>Official Name</color>**: DNA polymerase epsilon 2, accessory subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5427|5427]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56282|P56282]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602670|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in DNA repair and in chromosomal DNA replication.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol E B|
|Dpoe2NT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epsilon DNA polymerase complex|
|error-prone translesion synthesis|
|telomere maintenance via semi-conservative replication|
|DNA-directed DNA polymerase activity|
|DNA replication initiation|
|translesion synthesis|
|nuclear DNA replication|
|cell cycle DNA replication|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|telomere maintenance|
|telomere organization|
|DNA biosynthetic process|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|DNA replication|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear body|
|anatomical structure homeostasis|
|DNA repair|
|mitotic cell cycle process|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular homeostasis|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.04|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.97|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.71|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.73|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.77|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.84|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.84|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.9|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.93|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.02|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.14|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.15|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|2.16|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.17|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.24|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.25|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.25|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|2.42|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.42|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.46|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.54|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.59|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.482|
|[[:human genes:i:iscu|ISCU]]|0.458|
|[[:human genes:p:psmb4|PSMB4]]|0.45|
|[[:human genes:o:orc1|ORC1]]|0.446|
|[[:human genes:r:rps12|RPS12]]|0.442|
|[[:human genes:t:terf1|TERF1]]|0.429|
|[[:human genes:s:sf3a1|SF3A1]]|0.424|
|[[:human genes:c:cbwd5|CBWD5]]|0.416|
|[[:human genes:t:tceb3c|TCEB3C]]|0.409|
|[[:human genes:c:chd4|CHD4]]|0.406|
|[[:human genes:n:nupl1|NUPL1]]|0.405|
|[[:human genes:c:cbwd6|CBWD6]]|0.404|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.403|
|[[:human genes:i:igfn1|IGFN1]]|0.401|
|[[:human genes:t:tfip11|TFIP11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 114
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLE2 Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>