SF3A1

Gene Information

Official Symbol: SF3A1
Official Name: splicing factor 3a subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 10291
UniProt: Q15459
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014].
UniProt Summary: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.001μM R00 exp3	-2.98
5-Fluorouracil 20μM R00 exp2	-2.93
Hinokiflavone 12μM R08 exp487	-2.78
JQ1 0.8μM R08 exp435	-2.72
PU-H71 1μM R08 exp515	-2.64
42°C R08 exp539	-2.35
Actinomycin-D 0.01μM R00 exp4	-2.33
Benzoate 20000μM R08 exp456	-1.95
Vinblastine 0.2μM R03 exp108	-1.87
SB743921 0.001μM R05 exp244	-1.73
Cycloheximide 0.2μM R00 exp15	1.73
Sucrose 20000μM R06 exp298	1.79
Cabazitaxel 0.001μM R05 exp223	1.8
Dinaciclib 0.007μM R07 exp355	1.8
Alpha-Amanitin 0.5μM R00 exp5	1.81
Cidofovir 10μM R07 exp345	1.89
proTAME 5μM R04 exp187	1.91
VHL-ligand-1 20μM R07 exp421	1.92
Methotrexate 0.01μM R08 exp501	1.95
CAY10603 0.55μM R08 exp467	1.98
Etoposide 0.1μM R05 exp198	2.13
Doxycycline 10μM R00 exp18	2.22
UM0131023 0.05μM R05 exp248	2.4
ABT-702 5μM R07 exp318	2.41
CVT-10216 0.1μM R06 exp278	2.53
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	3.09

Gene	Correlation
HIST2H3A	0.543
HIST2H3C	0.542
TCEB3CL2	0.535
PSMB4	0.533
TCEB3C	0.516
C14orf93	0.514
VASN	0.513
ORC1	0.507
CDC6	0.507
RPL35	0.504
CHD4	0.501
TCEB3CL	0.499
C1QTNF9B	0.498
AAMP	0.498
RPS2	0.495
SUPT5H	0.493
POLR2F	0.491
BYSL	0.49
ISCU	0.483
TBC1D3H	0.481
NPIPB5	0.481
KIF3C	0.481
COPE	0.481
TBC1D3L	0.48
TBC1D3E	0.479
COPG1	0.479
PWP2	0.479
TBC1D3K	0.479
TBC1D3I	0.478
GOLGA6L6	0.476
TICRR	0.476
TBC1D3C	0.475
DIDO1	0.475
PAF1	0.474
IGFN1	0.473
HIST1H2BE	0.471
RBBP5	0.47
TFIP11	0.469
POLA2	0.467
CBWD5	0.467
TYMS	0.466
TBC1D3G	0.464
CBWD3	0.464
AQR	0.461
POLR2J3	0.46
SF3A2	0.456
PAN3	0.455
CDC73	0.455
CBWD6	0.454
DDTL	0.454
NUP160	0.454
CWC22	0.454
NARFL	0.454
NPIPB8	0.453
RBM39	0.452
ORC6	0.452
WDR75	0.452
COPB2	0.452
LRR1	0.451
SART1	0.451
RAD51	0.451
SNIP1	0.45
CEP192	0.45
COPB1	0.45
BRD2	0.448
MYO1H	0.446
PSMD11	0.446
PSMD1	0.446
RPS5	0.445
COPA	0.445
HAP1	0.444
MYB	0.443
CACTIN	0.441
PSMD14	0.441
SNRPA1	0.44
CCDC94	0.439
ZNF106	0.439
PRKCZ	0.438
COPZ1	0.437
RPS9	0.436
GOLGA8O	0.436
PSMD3	0.436
NUP62	0.435
POLE	0.433
TBC1D3F	0.433
NSF	0.433
ANKLE2	0.432
PSMA6	0.432
PSMB1	0.431
RPS12	0.43
STIL	0.429
MYH2	0.428
AKIRIN2	0.427
INTS6	0.427
CKAP5	0.426
MT1E	0.425
POLE2	0.424
DTL	0.424
LAD1	0.423
CHAF1A	0.423
ARHGEF15	0.423
AAAS	0.423
GGA3	0.423
IK	0.422
SF3B1	0.422
SEC13	0.422
HNRNPA1	0.421
RNF113A	0.421
EXOSC6	0.42
CGB2	0.42
CASC3	0.42
RPL14	0.42
GOLGA6L3	0.419
PLEKHA4	0.419
EIF3G	0.419
SNRNP70	0.419
SCAF1	0.419
HINFP	0.419
NCAPG	0.419
TERF1	0.418
TGFBRAP1	0.418
ATP6V1C1	0.418
XAB2	0.417
DISP2	0.417
RPS11	0.417
POLA1	0.416
UQCRH	0.416
NUP205	0.416
SF3A3	0.416
RRP7A	0.415
NUP133	0.415
TBC1D3	0.414
KCTD17	0.414
FANCM	0.413
GOLGA8J	0.413
GOLGA6L1	0.412
NUPL1	0.411
TSPY8	0.411
PRPF8	0.411
INTS5	0.41
PPFIA4	0.41
MYT1L	0.409
RPL7L1	0.408
PSMA7	0.407
TWISTNB	0.407
PSMB2	0.407
ZNF655	0.407
TIMELESS	0.406
TERF2	0.406
COX7A2L	0.405
TOP1MT	0.405
ADAMTSL4	0.404
HIVEP3	0.404
GPRIN2	0.403
PSMD7	0.403
RILPL1	0.402
SETD1A	0.402
NIP7	0.402
TAF1	0.401
WDR90	0.401

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 331
Expression level (log2 read counts): 7.54

Expression Distribution

Surp
ubiquitin
PRP21 like P

U2-type prespliceosome assembly
mRNA 3-splice site recognition
U2-type spliceosomal complex
U2-type prespliceosome
U2 snRNP
mRNA splice site selection
U2-type precatalytic spliceosome
spliceosomal complex assembly
catalytic step 2 spliceosome
spliceosomal complex
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
RNA binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression